Which target for DBS in Parkinson's disease? Subthalamic nucleus versus globus pallidus internus

被引：0

作者：

A. E. Scotto di Luzio

F. Ammannati

P. Marini

S. Sorbi

P. Mennonna

机构：

[1] Neurological Clinic I,

[2] University School of Medicine,undefined

[3] Careggi,undefined

[4] Florence,undefined

[5] Italy,undefined

[6] Neurosurgery Unit,undefined

[7] Careggi,undefined

[8] Florence,undefined

来源：

Neurological Sciences | 2001年 / 22卷

关键词：

Clinical Effect; Globus Pallidus; Subthalamic Nucleus; Motor Score; Globus Pallidus Internus;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We selected 14 patients with advanced idiopathic Parkinson's disease (PD) and examined the clinical effects of STN DBS versus GPi DBS. Nine patients underwent bilateral STN DBS and five underwent bilateral GPi patients. All patients were followed for at least 12 months. The evaluation was performed on and off drug before surgery; on-drug/on-DBS and off-drug/on-DBS at 1, 2, 6 and 12 months after stereotactic surgery. At 1 and 3 months after surgery in off-drug/on-DBS condition, both groups showed an improvement in motor score (UPDRS II). Nevertheless, the results changed after long-term stimulation in the two groups. Chronic STN DBS is superior to GPi DBS in the amelioration of the clinical features and in the decrease of time spent in the off state. The efficacy in reduction of LID was comparable at 1 and 3 months after surgery, but the results were better in STN DBS after chronic stimulation. The L-dopa dose was reduced only in the STN group.

引用

页码：87 / 88

页数：1