Evolution of DNA polymerase ι structure and function in eukaryotes

被引：0
作者：
A. V. Makarova
V. Z. Tarantul
L. V. Gening
机构：
[1] Russian Academy of Sciences,Institute of Molecular Genetics
来源：
Biochemistry (Moscow) | 2008年 / 73卷
关键词：
DNA polymerase ; error-prone activity; hypermutagenesis;
D O I：
暂无
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学科分类号：
摘要：
Analysis of DNA polymerase ι (Pol ι) enzymic activity in different classes of eukaryotes has shown that error-prone activity of this enzyme can be found only in mammals, and that it is completely absent from organisms that are at lower stages of development. It was supposed that the emergence of the error-prone Pol ι activity in mammals is caused by structural alteration of the active center. Possible functions of error-prone Pol ι in higher eukaryotes are discussed.
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页码：346 / 352
页数：6
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