Functional proteins of mesenchymal stem cell-derived extracellular vesicles

被引：0
作者：
Guanguan Qiu
Guoping Zheng
Menghua Ge
Jiangmei Wang
Ruoqiong Huang
Qiang Shu
Jianguo Xu
机构：
[1] Shaoxing Second Hospital,
[2] The Children’s Hospital of Zhejiang University School of Medicine,undefined
[3] The First Affiliated Hospital of Zhejiang University School of Medicine,undefined
来源：
Stem Cell Research & Therapy | / 10卷
关键词：
Mesenchymal stem/stromal cells; Extracellular vesicles; Exosomes; Microvesicles; Functional proteins;
D O I：
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学科分类号：
摘要：
Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs.
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