IL-6 gene amplification and expression in human glioblastomas

被引：0
作者：
A Tchirkov
C Rolhion
S Bertrand
J-F Doré
J-J Dubost
P Verrelle
机构：
[1] Centre Jean Perrin,
[2] Faculté de Médecine,undefined
[3] Laboratoire de Cytogénétique,undefined
[4] place Henri Dunant,undefined
[5] INSERM U484 rue Montalembert,undefined
[6] Centre Léon Bérard,undefined
[7] Unité d'Immunologie Clinique,undefined
[8] Service de Rhumatologie,undefined
[9] CHU – Hôpital Gabriel Montpied,undefined
来源：
British Journal of Cancer | 2001年 / 85卷
关键词：
gene amplification and expression; glioblastoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression. © 2001 Cancer Research Campaign http://www.bjcancer.com
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页码：518 / 522
页数：4
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