Effect of ginsenoside-Rb1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats

被引：0
作者：
Guan Li
Li Weizhen
Liu Zhengxiang
机构：
[1] Huazhong University of Science and Technology,Department of Cardiology, Tongji Hospital, Tongji Medical College
[2] Xiaogan Central Hospital,Department of Cardiology
[3] People's Hospital of Luohu District,undefined
来源：
Current Medical Science | 2002年 / 22卷 / 3期
关键词：
ginsenoside Rb; ischemia/reperfusion; cardiomyocyte apoptosis;
D O I：
10.1007/BF02828182
中图分类号：
学科分类号：
摘要：
The effect of ginsenoside Rb1 on cardiomyocyte apotosis after ischemia (30 min) and reperfusion (6 h) in rats was observed. The ischemia/reperfusion heart model was established by ligating left anterior descending branch of coronary artery in Wistar rats. The apoptotic cardiomyocytes were examined under transmission electron microscopy and counted byin situ nick end labeling (TUNEL) method and light microscopy. Results showed that (1) The apoptotic cardiomyocytes were found in ischemic regions in the ischemia/reperfusion group, but not in the sham-operating group under transmission electron microscopy; (2) The number of apoptotic cells were 134.45±45.61/field in the ischemia/reperfusion group, 0/field in the sham-operating group and 51.65±13.71/field in the ginsenoside Rb1-treated group. The differences were significant among the three groups (P<0.01). It was concluded that myocardial ischemia-reperfusion could induce cardiomyocyte apoptosis, and ginsenoside Rb1 could significantly inhibit cardiomyocyte apoptosis induced by ischemia-reperfusion in rats, indicating that ginsenoside Rb1 could inhibit cardiomyocyte apoptosis induced by ischemia-reperfusion, thus alleviating ischemia-reperfusion injury.
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页码：212 / 215
页数：3
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