Gentamicin pharmacokinetics in preterm infants with a patent and a closed ductus arteriosus

被引：0
作者：
D.J. Touw
J.H. Proost
R. Lafeber
H.N. Stevens
M.M. van Weissenbruch
机构：
[1] Vrije Universiteit Medical Center,Department of Pharmacy
[2] University Centre for Pharmacy,Department of Pharmacokinetics and Drug Delivery
[3] Vrije Universiteit Medical Center,Department of Pediatrics
来源：
Pharmacy World and Science | 2001年 / 23卷
关键词：
gentamicin; neonates; ductus arteriosus; pharmacokinetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background and aim: A patent ductus arteriosus (PDA) may influence renal and hepatic blood flow and hence pharmacokinetics of drugs in neonates compared to neonates with a closed ductus arteriosus (CDA). A 10‐percent difference of gentamicin pharmacokinetic parameters between PDA and CDA has been reported, but its implications are unclear. The relevance of this difference relative to the variability within the neonatal population was investigated.
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页码：200 / 204
页数：4
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