Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease

被引：0
作者：
Emine M. Onal
Baris Afsar
Adrian Covic
Nosratola D. Vaziri
Mehmet Kanbay
机构：
[1] Koc University School of Medicine,Department of Medicine
[2] Suleyman Demirel University School of Medicine,Department of Medicine, Division of Nephrology
[3] ‘C.I. PARHON’ University Hospital,Nephrology Clinic, Dialysis and Renal Transplant Center
[4] and ‘Grigore T. Popa’ University of Medicine,Division of Nephrology and Hypertension, Schools of Medicine and Biological Science
[5] University of California,Department of Medicine, Division of Nephrology
[6] Koc University School of Medicine,undefined
来源：
Hypertension Research | 2019年 / 42卷
关键词：
Gut microbiota; Chronic kidney disease; Uremic toxins; Cardiovascular disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The health and proper functioning of the cardiovascular and renal systems largely depend on crosstalk in the gut–kidney–heart/vessel triangle. Recent evidence suggests that the gut microbiota has an integral function in this crosstalk. Mounting evidence indicates that the development of chronic kidney and cardiovascular diseases follows chronic inflammatory processes that are affected by the gut microbiota via various immune, metabolic, endocrine, and neurologic pathways. Additionally, deterioration of the function of the cardiovascular and renal systems has been reported to disrupt the original gut microbiota composition, further contributing to the advancement of chronic cardiovascular and renal diseases. Considering the interaction between the gut microbiota and the renal and cardiovascular systems, we can infer that interventions for the gut microbiota through diet and possibly some medications can prevent/stop the vicious cycle between the gut microbiota and the cardiovascular/renal systems, leading to a decrease in chronic cardiovascular and renal diseases.
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页码：123 / 140
页数：17
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