Stability—Indicating assay for haloperidol syrup by high-performance liquid chromatography

被引：0
|
作者：
R. Driouich
H. Trabelsi
K. A. Bouzouita
机构：
[1] Okayama University,Department of Chemistry, Faculty of Science
[2] Laboratoire National de Controle des Medicaments,undefined
来源：
Chromatographia | 2001年 / 53卷
关键词：
Column liquid chromatography; Optimization; Degradation products; Benzoic acids, 4-(4-Chlorophenyl)-4-hydroxypiperidine; Haloperidol, methylparaben, and propylparaben;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A Snyder selectivity triangle was approved for the optimization of a reversed-phases HPLC separation of haloperidol, methylparaben and propylparaben in the presence of their degradation products. The degradation products considered were: 4-(4-chlorophenyl)-4-hydroxypiperidine and 4-fluorobenzoic acid presumed to be hydrolytic products of haloperidol, and 4-hydroxybenzoic presumed to be a hydrolytic product of parabens.
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页码：629 / 634
页数：5
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