Stem cell therapy for central nervous system demyelinating disease

被引：15
作者：
Manganas L.N. [1 ]
Maletic-Savatic M. [1 ]
机构：
[1] Department of Neurology, Stony Brook University, Stony Brook
来源：
Current Neurology and Neuroscience Reports | 2005年 / 5卷 / 3期
关键词：
Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Neural Stem Cell; Stem Cell Therapy; Bone Marrow Stem Cell;
D O I：
10.1007/s11910-005-0050-z
中图分类号：
学科分类号：
摘要：
Recent advances in cell-based therapies for demyelinating central nervous system diseases have demonstrated the ability to restore damaged neuronal architecture and function. Demyelinated axons in patients with multiple sclerosis can spontaneously remyelinate over time; however, the rate and extent at which remyelination occurs is inadequate for complete recovery. Previous attempts aimed at regenerating myelin-forming cells have been successful but limited by the multifocal nature of the lesions and the inability to produce large numbers of myelin-producing cells in culture. Stem cell-based therapy can overcome these limitations to some extent and may prove useful in the future treatment of demyelinating diseases. Copyright © 2005 by Current Science Inc.
引用
收藏
页码：225 / 231
页数：6
相关论文
共 73 条
[1]  
Rasband M.N., Kagawa T., Park E.W., Et al., Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination, J. Neurosci. Res., 73, pp. 465-470, (2003)
[2]  
Rasband M.N., Trimmer J.S., Peles E., Et al., K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve, J. Neurocytol., 28, pp. 131-319, (1999)
[3]  
Hemmer B., Archelos J.J., Hartung H.P., New concepts in the immunopathogenesis of multiple sclerosis, Nat. Rev. Neurosci., 4, pp. 291-301, (2002)
[4]  
Lassman H., Bruck W., Lucchinetti C., Et al., Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy, Trends Mol. Med., 7, pp. 115-121, (2001)
[5]  
Murray P.D., McGavern D.B., Sathornsumetee S., Et al., Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis, Brain, 124, pp. 1403-1416, (2001)
[6]  
Franklin R.J., Why does remyelination fail in multiple sclerosis?, Nat. Rev. Neurosci., 3, pp. 705-714, (2001)
[7]  
Blakemore W.F., Pattern of remyelination in the CNS, Nature, 249, pp. 577-578, (1974)
[8]  
Mathisen P.M., Kawczak J.A., Yu M., Et al., Differential DM20 mRNA expression distinguishes two distinct patterns of spontaneous recovery from murine autoimmune encephalomyelitis, J. Neurosci. Res., 64, pp. 542-551, (2001)
[9]  
Barkhof F., Bruck W., De Groot C.L., Et al., Remyelinated lesions in multiple sclerosis: Magnetic resonance imaging appearance, Arch. Neurol., 60, pp. 1073-1081, (2003)
[10]  
Lucchinetti C., Bruck W., Parisi J., Et al., A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases, Brain, 122, pp. 2279-2295, (1999)
12345678