Innovations in pharmacotherapy for stress urinary incontinence

被引：3
作者：
Tracy W. Cannon
Naoki Yoshimura
Michael B. Chancellor
机构：
[1] Department of Urology, Univesity of Pittsburgh, Pittsburgh, PA 15213
来源：
International Urogynecology Journal | 2003年 / 14卷 / 6期
基金：
美国国家卫生研究院;
关键词：
Duloxetine; Serotonin; Stress urinary incontinence; Urethra;
D O I：
10.1007/s00192-003-1093-9
中图分类号：
学科分类号：
摘要：
The purpose of this review article is to highlight new pharmacotherapies on the horizon for the treatment of stress urinary incontinence (SUI). Although behavioral and surgical therapies are currently the mainstay of treating SUI, we believe that medications will take center stage and possibly become first-line therapy. Currently, there are no FDA medications indicated for SUI. However, results are becoming available about an oral medication, duloxetine, which appears to be clinically safe and efficacious for the treatment of SUI. In addition to discussing medications currently under development, we will also discuss exciting pharmacological targets that could be suitable to treat SUI.
引用
收藏
页码：367 / 372
页数：5
相关论文
共 40 条
  • [1] Retzky S.S., Rogers R.M.J., Urinary incontinence in women, Clin. Symp., 47, pp. 2-32, (1995)
  • [2] Norton P.A., Etiology of genuine stress incontinence, The Female Pelvic Floor: Disorders of Function and Support, pp. 153-157, (1996)
  • [3] Peschers U., Schaer G., Anthuber C., Delancey J.O., Schuessler B., Changes in vesical neck mobility following vaginal delivery, Obstet. Gynecol., 88, pp. 1001-1006, (1996)
  • [4] Thom D.H., van den Eeden S.K., Brown J.S., Evaluation of parturition and other reproductive variables as risk factors for urinary incontinence in later life, Obstet. Gynecol., 90, pp. 983-989, (1997)
  • [5] Meyer S., Schreyer A., DeGrandi P., Hohlfeld P., The effects of birth on urinary continence mechanisms and other pelvic-floor characteristics, Obstet. Gynecol., 92, pp. 613-618, (1998)
  • [6] Sampselle C.M., Miller J.M., Mims B.L., DeLancey J.O., Ashton-Miller J.A., Antonakos C.L., Effect of pelvic muscle exercise on transient incontinence during pregnancy and after birth, Obstet. Gynecol., 91, pp. 406-412, (1998)
  • [7] Snooks S.J., Badenock D.F., Tiptaft R.C., Swash M., Perineal nerve damage in genuine stress incontinence: An electrophysiology study, Br. J. Urol., 57, pp. 422-426, (1985)
  • [8] Snooks S.J., Swash M., Henry M.M., Setchell M., Risk factors in childbirth causing damage to the pelvic floor, Int. J. Colored Dis., 1, pp. 20-24, (1986)
  • [9] Smith A.R.B., Hosker G.L., Warrell D.W., The role of pudendal nerve damage in the aetiology of genuine stress incontinence in women, Br. J. Obstet. Gynecol., 96, pp. 29-32, (1989)
  • [10] Allen R.E., Hosker G.L., Smith A.R.B., Warrell D.W., Pelvic floor damage and childbirth: A neurophysiological study, Brit. J. Obstet. Gynecol., 97, pp. 770-779, (1990)
1234