Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age

被引：23

作者：

Goncharenko V.M. ^{[1
]}

Beniuk V.A. ^{[2
]}

Kalenska O.V. ^{[1
]}

Demchenko O.M. ^{[3
]}

Spivak M.Y. ^{[3
,4
]}

Bubnov R.V. ^{[1
,4
,5
]}

机构：

[1] Clinical Hospital ‘Pheophania’ of State Affairs Department, Zabolotny str., 21, Kyiv

[2] Third Department of Obstetrics and Gynecology, Bogomolets National Medical University, Kyiv

[3] JSC SPC ‘DiaprofMed’, Svitlycky str., 35, Kyiv

[4] Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv

[5] Center of Ultrasound Diagnostics and Interventional Sonography, Clinical Hospital ‘Pheophania’ of State Affairs Department, Zabolotny str., 21, Kyiv

来源：

EPMA Journal | 2013年 / 4卷 / 1期

关键词：

Endometrial hyperplasia; Endometrial receptors; Endoscopic treatment; Fertile age women; Hysteroresection; Personalized medicine; Predictive; Preventive; Sonoelastography; Transvaginal ultrasonography; Women’s health;

D O I：

10.1186/1878-5085-4-24

中图分类号：

学科分类号：

摘要：

Introduction: Endometrial hyperplasia has a high risk for malignant transformation and relapses; existing mini-invasive treatments may lead to irrevocable endometrium destruction. The aims were to analyze receptor systems in endometrial hyperplasia, to evaluate the capabilities of ultrasonography, sonoelastography for diagnosis and treatment control, and to develop treatment algorithm. Materials and methods: We included 313 women (20–45 years), assessed into the following: group 1 (n = 112) with glandular cystic hyperplasia, group 2 (n = 98) endometrial polyps, and group 3 (n = 103) atypical hyperplasia; and 82 controls who have undergone hysteroscopy before in vitro fertilization in tubal origin infertility were also included. Patients underwent clinical examination, transvaginal ultrasound, immunohistochemical study, and hormonal therapy/hysteroresectoscopy. Results: In patients with glandular hyperplasia, we registered increase of endometrium estrogen receptors (75.6% in the epithelium and 30.9% in the stroma; in controls, 43.3% and 29.6%, respectively); in polyps, there was a significant estrogen receptor increase in the stroma (48.2% vs 29.6% in controls), and in atypical hyperplasia, progesterone receptors significantly increased in the stroma. Ki-67 increased (40% to 50%) in the epithelium without changes in the stroma. Ultrasound has a sensitivity of 96% and a specificity of 85% for early detection of endometrial pathology and prediction outcome of intervention, and sonoelastography has a sensitivity of 91% and a specificity of 83% for polyp diagnosis. Personalized treatment was effective in 88.8%, relapse was diagnosed in 11.2% after 6 months, and conservative treatment of atypical hyperplasia was effective in 45%: in 25.8%, ablative hysteroresectoscopy was performed, while in 22.6% with comorbidities, hystero/oophorectomies were performed. Conclusions: The evaluation of receptor status with ultrasound data in patients with endometrial hyperplasia allows for a clear definition of the treatment policy, avoidance of relapse, treatment optimization, and observation of such patients. © 2013 Goncharenko et al.

引用

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