Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

被引：0
作者：
Barry J. Goldstein
Faiyaz Ahmad
Wendi Ding
Pei-Ming Li
Wei-Ren Zhang
机构：
[1] Dorrance H. Hamilton Research Laboratories,Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University
来源：
Molecular and Cellular Biochemistry | 1998年 / 182卷
关键词：
insulin action; transmembrane signalling; insulin resistance; tyrosine kinase; insulin receptor; receptor internalization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Protein-tyrosine phosphatases (PTPases) have been implicated in the physiological regulation of the insulin signalling pathway. In cellular and molecular studies, the transmembrane, receptor-type PTPase LAR and the intracellular, non-receptor enzyme PTP1B have been shown to have a direct impact on insulin action in intact cell models. Since insulin signalling can be enhanced by reducing the abundance or activity of specific PTPases, pharmaceutical agents directed at blocking the interaction between individual PTPases and the insulin receptor may have potential clinical relevance to the treatment of insulin-resistant states such as obesity and Type II diabetes mellitus.
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页码：91 / 99
页数：8
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