Enzymatic synthesis of nucleotide sugars

被引：0
作者：
Thomas Bülter
Lothar Elling
机构：
[1] University of Düsseldorf,Institute of Enzyme Technology
[2] Research Center Jülich,undefined
来源：
Glycoconjugate Journal | 1999年 / 16卷
关键词：
enzymatic synthesis; nucleotide sugars; ADP; Adenosine 5′9-diphosphate; CDP; Cytidine 5′9-diphosphate; CMP; Cytidine 5′9-monophosphate; CMP-Neu5Ac; Cytidine 5′9-monophospho-N-acetyl-β-D-neuraminic acid; CTP; Cytidine 5′9-triphosphate; dTDP; 2′9-deoxythymidine 5′9-diphosphate; dUDP; 2′9-deoxyuridine 5′9-diphosphate; EMR; enzyme membrane reactor; Fru; D-fructose; Fru-6-P; D-fructose 6-phosphate; Fuc; L-fucose; Fuc-1-P; β-L-fucose 1-phosphate; Gal; D-galactose; Gal-1-P; α-D-galactose 1-phosphate; GalN; D-galactosamine; GalN-1-P; α-D-galactosamine 1-phosphate; GalNAc; N-acetyl-D-galactosamine; GalNAc-1-P; N-acetyl-α-D-galactosamine 1-phosphate; GDP; Guanosine 5′9-diphosphate; GDP-6-d-4-k-L-Gal; Guanosine 5′9-diphospho-6-deoxy-4-keto-β-L-galactose; GDP-6-d-4-k-Man; Guanosine 5′9-diphospho-6-deoxy-4-keto-α-D-mannose; GDP-Fuc; Guanosine 5′9-diphospho-β-L-fucose; GDP-Fuc PP; Guanosine 5′9-diphospho-β-L-fucose pyrophosphorylase; GDP-Man; Guanosine 5′9-diphospho-α-D-mannose; GDP-Man DHy; GDP-mannose-4,6-dehydratase (EC 4.2.1.47); GDP-Man PP; GDP-man pyrophosphorylase (EC 2.7.7.13); Glc-1-P; D-glucose 1-phosphate; Glc-6-P; D-glucose 6-phosphate; GlcA-1-P; α-D-glucuronic acid 1-phosphate; GlcN; D-glucosamine; GlcN-1-P; α-D-glucosamine 1-phosphate; GlcN-6-P; D-glucosamine 6-phosphate; GlcNAc; N-acetyl-D-glucosamine; GlcNAc-1-P; N-acetyl-α-D-glucosamine 1-phosphate; GlcNAc-6-P; N-acetyl-D-glucosamine 6-phosphate; GlmU; glucosamine uridyltransferase; GTP; Guanosine 5′9-triphosphate; LacNAc; N-acetyllactosamine; Le; Lewis X antigen; Man; D-mannose; Man-1-P; α-D-mannose 1-phosphate; Man-6-P; D-mannose 6-phosphate; ManNAc; N-acetyl-D-mannose; ManNAc-6-P; N-acetyl-D-mannose 6-phosphate; NAD; nicotinamide adenine dinucleotide; NADH; nicotinamide adenine dinucleotide hydride; NADP; nicotinamide adenine dinucleotide phosphate; NADPH; nicotinamide adenine dinucleotide phosphate hydride; NAS; N-acetoxysuccinimide; Neu5Ac; N-acetylneuraminic acid; Neu5Ac-9-P; N-acetylneuraminic acid 9-phosphate; NeuAc aldolase; N-acetylneuraminic acid aldolase (EC 4.1.3.3); NMPK; nucleoside 5′9-monophosphate kinase (EC 2.7.7.4); PEP; phosphoenolpyruvate; PP; pyrophosphorylase; P; inorganic phosphate; PP; inorganic pyrophosphate; PGM; phosphoglucomutase (EC 2.7.5.1); PK; pyruvate kinase (EC 2.7.1.40); PMI; phosphomannose isomerase (EC 5.3.1.8); PMM; phosphomannomutase (EC 5.4.2.8); Pyr; pyruvate; UDP; uridine 5′9-diphosphate; UDP-Gal; uridine 5′9-diphospho-α-D-galactose; UDP-GalNAc; uridine 5′9-diphospho-N-acetyl-α-D-galactosamine; UDP-GalN; uridine 5′9-diphospho-α-D-galactosamine; UDP-Glc; uridine 5′9-diphospho-α-D-glucose; UDP-Glc DH; UDP-glucose dehydrogenase; UDP-GlcA; uridine 5′9-diphospho-α-D-glucuronic acid; UDP-GlcNAc; uridine 5′9-diphospho-N-acetyl-α-D-glucosamine; UDP-Xyl; uridine 5′9-diphospho-α-D-xylose; UMP; uridine 5′9-monophosphate;
D O I：
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学科分类号：
摘要：
The present review gives a survey on the biosynthetic pathways of nucleotide sugars which are important for the in vitro synthesis of mammalian glycoconjugates. With respect to the use of these enzymes in glycotechnology the availability as recombinant enzymes from different sources, the large-scale synthesis of nucleotide sugars and their in situ regeneration in combination with glycosyltransferases are summarized and evaluated.
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页码：147 / 159
页数：12
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