NF-κB, stem cells and breast cancer: the links get stronger

被引：0
作者：
Kateryna Shostak
Alain Chariot
机构：
[1] University of Liege,Interdisciplinary Cluster for Applied Genoproteomics (GIGA
来源：
Breast Cancer Research | / 13卷
关键词：
Breast Cancer; DMBA; Breast Cancer Stem Cell; Luminal Progenitor Cell; 1q32 Amplicon;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and in treatment resistance and relapse. The molecular pathways required for their maintenance are starting to be elucidated. Among them is the transcription factor NF-κB, which is known to play critical roles in cell survival, inflammation and immunity. Recent studies indicate that mammary epithelial NF-κB regulates the self-renewal of breast cancer stem cells in a model of Her2-dependent tumourigenesis. We will describe here the NF-κB-activating pathways that are involved in this process and in which progenitor cells this transcription factor is actually activated.
引用
收藏
相关论文
共 323 条
[1]  
Hayden MS(2008)Shared principles in NF-kappa B signaling Cell 132 344-362
[2]  
Ghosh S(2002)NF-kappa B at the crossroads of life and death Nat Immunol 3 221-227
[3]  
Karin M(2001)Nuclear factor-kB (NF-kB) regulates proliferation and branching in mouse mammary epithelium Mol Biol Cell 12 1445-1455
[4]  
Lin A(2001)IKK alpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development Cell 107 763-775
[5]  
Brantley DM(1997)Aberrant nuclear factor-kappa B/Rel expression and the pathogenesis of breast cancer J Clin Invest 100 2952-2960
[6]  
Chen CL(2004)NF-kB activation in human breast cancer specimens and its role in cell proliferation and apoptosis Proc Natl Acad Sci USA 101 10137-10142
[7]  
Muraoka RS(1997)Constitutive activation of NF-kappa B during progression of breast cancer to hormone-independent growth Mol Cell Biol 17 3629-3639
[8]  
Bushdid PB(2011)Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden Oncogene 30 1402-1412
[9]  
Bradberry JL(2004)NF-kappa B is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression J Clin Invest 114 569-581
[10]  
Kittrell F(2007)NF-kappa B represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2 Oncogene 26 711-724
12345678910