Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients

被引：0

作者：

B. Trevisan

F. F. Pepe

I. Vallini

E. Montagna

D. Amoroso

R. Berardi

A. Butera

K. Cagossi

L. Cavanna

M. Ciccarese

S. Cinieri

E. Cretella

E. De Conciliis

A. Febbraro

F. Ferraù

A. Ferzi

A. Baldelli

A. Fontana

A. R. Gambaro

O. Garrone

V. Gebbia

D. Generali

L. Gianni

F. Giovanardi

A. Grassadonia

V. Leonardi

S. Sarti

A. Musolino

M. Nicolini

C. Putzu

F. Riccardi

D. Santini

M. G. Sarobba

M. G. Schintu

G. Scognamiglio

P. Spadaro

C. Taverniti

D. Toniolo

P. Tralongo

A. Turletti

R. Valenza

M. R. Valerio

P. Vici

L. Clivio

V. Torri

M. E. Cazzaniga

机构：

[1] Azienda Ospedaliera San Gerardo,

[2] Ospedale di Circolo e Fondazione Macchi,undefined

[3] European Institute of Oncology,undefined

[4] Ospedale Versilia,undefined

[5] Azienda Ospedaliera Universitaria Ospedali Riuniti,undefined

[6] Nuovo Ospedale San Giovanni Di Dio,undefined

[7] Ospedale Ramazzini,undefined

[8] Azienda Ospedaliera Piacenza,undefined

[9] Ospedale Vito Fazzi,undefined

[10] Ospedale A. Perrino,undefined

[11] Ospedale Bolzano,undefined

[12] ASL Asti,undefined

[13] Ospedale S. Cuore di Gesù Fatebenefratelli,undefined

[14] Ospedale San Vincenzo,undefined

[15] Azienda Ospedaliera Ospedale Civile Di Legnano,undefined

[16] Ospedale San Salvatore,undefined

[17] Azienda Ospedaliero-Universitaria Pisana,undefined

[18] ASST Fatebenefratelli Sacco,undefined

[19] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined

[20] Ospedale La Maddalena,undefined

[21] Istituti Ospitalieri Cremona,undefined

[22] Ospedale Infermi,undefined

[23] AUSL della Romagna,undefined

[24] Ospedale SS Annunziata,undefined

[25] Ospedale Civico,undefined

[26] IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori,undefined

[27] Ospedale di Parma,undefined

[28] Azienda Ospedaliera-Universitaria,undefined

[29] Ospedale Antonio Cardarelli,undefined

[30] Università Campus Bio-Medico,undefined

[31] Ospedale San Francesco,undefined

[32] Ospedale Giovanni Paolo II,undefined

[33] Ospedale Valduce,undefined

[34] Casa di Cura Villa Salus-Messina,undefined

[35] Ospedale Molinette,undefined

[36] Ospedale di Circolo,undefined

[37] Ospedale Umberto I,undefined

[38] Ospedale Martini,undefined

[39] P.O. Vittorio Emanuele,undefined

[40] A.O.U. Policlinico Paolo Giaccone,undefined

[41] INT Regina Elena,undefined

[42] IRCCS Mario Negri Institute of Pharmacological Research,undefined

来源：

Scientific Reports | / 13卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Nowadays, treatment of metastatic breast cancer (MBC) has been enriched with novel therapeutical strategies. Metronomic chemotherapy (mCHT) is a continuous and frequent administration of chemotherapy at a lower dose and so whit less toxicity. Thus, this strategy could be attractive for elderly MBC patients. Aim of this analysis is to provide insights into mCHT’s activity in a real-life setting of elderly MBC patients. Data of patients ≥ 75 years old included in VICTOR-6 study were analyzed. VICTOR-6 is a multicentre, Italian, retrospective study, which collected data on mCHT in MBC patients treated between 2011 and 2016. A total of 112 patients were included. At the beginning of mCHT, median age was 81 years (75–98) and in 33% of the patients mCHT was the first line choice. Overall Response Rate (ORR) and Disease Control Rate (DCR) were 27.9% and 79.3%, respectively. Median PFS ranged between 7.6 and 9.1 months, OS between 14.1 and 18.5 months. The most relevant toxicity was the hematological one (24.1%); severe toxicity (grade 3–4) ranged from 0.9% for skin toxicity up to 8% for hematologic one. This is a large study about mCHT in elderly MBC patients, providing insights to be further investigated in this subgroup of frail patients.

引用

共 50 条

[1] Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients
Trevisan, B.
Pepe, F. F.
Vallini, I.
Montagna, E.
Amoroso, D.
Berardi, R.
Butera, A.
Cagossi, K.
Cavanna, L.
Ciccarese, M.
Cinieri, S.
Cretella, E.
De Conciliis, E.
Febbraro, A.
Ferrau, F.
Ferzi, A.
Baldelli, A.
Fontana, A.
Gambaro, A. R.
Garrone, O.
Gebbia, V.
Generali, D.
Gianni, L.
Giovanardi, F.
Grassadonia, A.
Leonardi, V.
Sarti, S.
Musolino, A.
Nicolini, M.
Putzu, C.
Riccardi, F.
Santini, D.
Sarobba, M. G.
Schintu, M. G.
Scognamiglio, G.
Spadaro, P.
Taverniti, C.
Toniolo, D.
Tralongo, P.
Turletti, A.
Valenza, R.
Valerio, M. R.
Vici, P.
Clivio, L.
Torri, V.
Cazzaniga, M. E.
SCIENTIFIC REPORTS, 2023, 13 (01)
[2] Metronomic chemotherapy for advanced breast cancer patients in the real world practice: Final results of the VICTOR-6 study
Cazzaniga, M. E.
Pinotti, G.
Montagna, E.
Amoroso, D.
Berardi, R.
Butera, A.
Cagossi, K.
Cavanna, L.
Ciccarese, M.
Cinieri, S.
Cretella, E.
De Conciliis, E.
Febbraro, A.
Ferrau, F.
Ferzi, A.
Fiorentini, G.
Fontana, A.
Gambaro, A. R.
Garrone, O.
Gebbia, V
Generali, D.
Gianni, L.
Giovanardi, F.
Grassadonia, A.
Leonardi, V
Marchetti, P.
Melegari, E.
Musolino, A.
Nicolini, M.
Putzu, C.
Riccardi, F.
Santini, D.
Saracchini, S.
Sarobba, M. G.
Schintu, M. G.
Scognamiglio, G.
Spadaro, P.
Taverniti, C.
Toniolo, D.
Tralongo, P.
Turletti, A.
Valenza, R.
Valerio, M. R.
Vici, P.
Clivio, L.
Torri, V
Cicchiello, F.
Riva, F.
Vallini, I
Mazza, M.
BREAST, 2019, 48 : 7 - 16
[3] Metronomic chemotherapy (mCHT) in metastatic triple-negative breast cancer (TNBC) patients: results of the VICTOR-6 study
Cazzaniga, E.
Vallini, I
Montagna, E.
Amoroso, D.
Berardi, R.
Butera, A.
Cagossi, K.
Cavanna, L.
Ciccarese, M.
Cinieri, S.
Cretella, E.
De Conciliis, E.
Febbraro, A.
Ferrau, F.
Ferzi, A.
Baldelli, A.
Fontana, A.
Gambaro, A. R.
Garrone, O.
Gebbia, V
Generali, D.
Gianni, L.
Giovanardi, F.
Grassadonia, A.
Leonardi, V
Marchetti, P.
Sarti, S.
Musolino, A.
Nicolini, M.
Putzu, C.
Riccardi, F.
Santini, D.
Saracchini, S.
Sarobba, M. G.
Schintu, M. G.
Scognamiglio, G.
Spadaro, P.
Taverniti, C.
Toniolo, D.
Tralongo, P.
Turletti, A.
Valenza, R.
Valerio, M. R.
Vici, P.
Di Mauro, P.
Cogliati, V
Capici, S.
Clivio, L.
Torri, V
BREAST CANCER RESEARCH AND TREATMENT, 2021, 190 (03) : 415 - 424
[4] Metronomic chemotherapy (mCHT) in metastatic triple-negative breast cancer (TNBC) patients: results of the VICTOR-6 study
M. E. Cazzaniga
I. Vallini
E. Montagna
D. Amoroso
R. Berardi
A. Butera
K. Cagossi
L. Cavanna
M. Ciccarese
S. Cinieri
E. Cretella
E. De Conciliis
A. Febbraro
F. Ferraù
A. Ferzi
A. Baldelli
A. Fontana
A. R. Gambaro
O. Garrone
V. Gebbia
D. Generali
L. Gianni
F. Giovanardi
A. Grassadonia
V. Leonardi
P. Marchetti
S. Sarti
A. Musolino
M. Nicolini
C. Putzu
F. Riccardi
D. Santini
S. Saracchini
M. G. Sarobba
M. G. Schintu
G. Scognamiglio
P. Spadaro
C. Taverniti
D. Toniolo
P. Tralongo
A. Turletti
R. Valenza
M. R. Valerio
P. Vici
P. Di Mauro
V. Cogliati
S. Capici
L. Clivio
V. Torri
Breast Cancer Research and Treatment, 2021, 190 : 415 - 424
[5] Metronomic chemotherapy (mCHT) in HER2-ve advanced breast cancer (ABC) patients (pts): Final results of the VICTOR-6 study.
Cazzaniga, Marina Elena
Scognamiglio, Giovanni
Generali, Daniele Giulio
Ferzi, Antonella
Vandone, Anna Maria
Spadaro, Pietro
Mocerino, Carmela
Montagna, Emilia
Cretella, Elisabetta
Gambaro, Anna
Taverniti, Cristiana
Turletti, Anna
Sarobba, Giuseppina
Iezzi, Laura
Roberto, Michela
Ciccarese, Mariangela
Tralongo, Paolo
Clivio, Luca
Pedroli, Stefania
Torri, Valter
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
[6] Chemotherapy in elderly patients with metastatic breast cancer (MBC)
Wildiers, H.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2007, 64 : S18 - S18
[7] Metronomic chemotherapy (mCHT) in HER2-ve advanced breast cancer (ABC) patients (pts): old drugs, new results. The multicenter VICTOR-6 study
Cazzaniga, M.
Orlando, L.
Melegari, E.
Arcangeli, V.
Butera, A.
Pinotti, G.
Vallini, I.
Mocerino, C.
Giovanardi, F.
Cretella, E.
Gambaro, A.
Pistelli, M.
Donati, S.
Pizzuti, L.
Spagnuolo, A.
Putzu, C.
Leonardi, V.
De Angelis, C.
Pedroli, S.
Torri, V.
ANNALS OF ONCOLOGY, 2017, 28
[8] Metronomic chemotherapy (mCHT) in HER2-ve advanced breast cancer (ABC) patients (pts): Old drugs, new opportunities Preliminary results of the VICTOR-6 study
Cazzaniga, M.
Cagossi, K.
Valerio, M. R.
Russo, S.
Casadei, V.
Scognamiglio, G.
Cavanna, L.
Toniolo, D.
De Conciliis, E.
Melegari, E.
Stocchi, L.
Gebbia, V.
Vandone, A. M.
Cursano, M. C.
Pinotti, G.
Rossello, R.
Ortu, S.
Pellegrino, B.
Saracchini, S.
Torri, V.
ANNALS OF ONCOLOGY, 2017, 28
[9] A metronomic treatment with oral chemotherapy in elderly patients with metastatic breast cancer
Vitello, S.
Triglia, E.
Giarratana, G.
Mangione, M.
Di Girolamo, G.
ANNALS OF ONCOLOGY, 2006, 17 : VII147 - VII147
[10] A METRONOMIC TREATMENT WITH ORAL CHEMOTHERAPY IN PATIENTS ELDERLY WITH METASTATIC BREAST CANCER
Vitello, S.
Maiorana, O. Dssa
Giarratano, G.
Triglia, E.
Mangione, M.
Di Cristina, L.
EJC SUPPLEMENTS, 2008, 6 (14): : 116 - 117

← 1 2 3 4 5 →