Antibacterial and immunomodulatory activities of bovine lactoferrin against Escherichia coli O157:H7 infections in cattle

被引：0
作者：
Evelien Kieckens
Joanna Rybarczyk
Eric Cox
Daisy Vanrompay
机构：
[1] Ghent University,Laboratory of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering
[2] Ghent University,Laboratory of Immunology, Faculty of Veterinary Medicine
来源：
BioMetals | 2018年 / 31卷
关键词：
Cattle; O157:H7; Bovine lactoferrin; Rectal administration; Shiga toxin; Interleukin 6;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E. coli O157:H7 infections in cattle. This paper provides an overview of latest research data on eradicating enterohemorrhagic E. coli O157:H7 in ruminants by use of bovine lactoferrin administration. The article provides insights into the anti-microbial and immunomodulatory activities of bovine lactoferrin against E. coli O157:H7 infections in cattle.
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页码：321 / 330
页数：9
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