Effect of Copper on Levels of Collagen and Alkaline Phosphatase Activity from Chondrocytes in Newborn Piglets In Vitro

被引：6
作者：
Xue Yuan
Jianguo Wang
Xiaoyan Zhu
Zhigang Zhang
Yongxing Ai
Guoquan Sun
Zhe Wang
Guowen Liu
机构：
[1] Jilin University,College of Animal Science and Veterinary Medicine
[2] Inner Mongolia National University,College of Animal Science and Technology
[3] Northeast Agriculture University,College of Veterinary Medicine
来源：
Biological Trace Element Research | 2011年 / 144卷
关键词：
Copper; Collagen; Chondrocyte; Alkaline phosphatase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effects of different concentrations of copper on collagen content and alkaline phosphatase (AKP) activity from chondrocytes in newborn piglets were measured. Chondrocytes were cultured in media containing 15% fetal calf serum supplemented with 0, 15.6, 31.2, and 62.5 μmol/L copper in a 12-well culture plate. Collagen content and AKP activity from the chondrocyte extracellular matrix increased significantly in the culture media with 15.6, 31.2, and 62.5 μmol/L copper and was the highest at 31.2 μmol/L copper (P < 0.05). Thus, the results indicated that copper could promote AKP activity and collagen production by chondrocytes.
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页码：597 / 605
页数：8
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