Jaw Osteonecrosis Associated with Use of Bisphosphonates and Chemotherapy: Paradoxical Complication of Treatment of Bone Lesions in Multiple Myeloma Patients

被引：0
作者：
Silvana Capalbo
Mario Delia
Daniela Diomede
Michelina Dargenio
Antonia Chiefa
Gianfranco Favia
Vincenzo Liso
机构：
[1] University of Bari Policlinico,Hematology Section, Department of Internal Medicine and Public Medicine
[2] University of Bari Policlinico,Department of Dental Science and Surgery
来源：
International Journal of Hematology | 2006年 / 83卷
关键词：
Bisphosphonates; Osteonecrosis; Jaw bones; Multiple myeloma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
It has been demonstrated that bisphosphonate-based supportive therapy (pamidronate or zoledronate) reduces skeletal events (onset or progression of osteolytic lesions) both in patients with multiple myeloma (MM) and in cancer patients with bone metastasis. Bisphosphonates (eg, alendronate) are also indicated in the treatment of osteoporosis. Nevertheless, osteonecrosis of the jaw (ONJ) has been reported in some patients being treated with bisphosphonates. We present a series of 9 MM patients who developed ONJ after treatment with bisphosphonates and chemotherapy. All the patients in this case series had undergone tooth extraction for recurrent dental abscesses while taking bisphosphonates. We also review the diagnostic and therapeutic implications of this paradoxical complication associated with treatment of bone lesions in MM.
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页码：439 / 442
页数：3
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