Gynecological endocrinology and reproductive medicine: Current aspects

被引:0
作者
Ludwig M. [2 ]
Montag M. [1 ,3 ]
Nawroth F. [2 ]
Strowitzki T. [3 ]
Toth B. [3 ]
机构
[1] ilabcomm, St. Augustin, St. Augustin
[2] Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie im Barkhof, Hamburg
[3] Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitäts-Frauenklinik Heidelberg, Heidelberg
来源
Der Gynäkologe | 2014年 / 47卷 / 9期
关键词
Abortion; Assisted reproduction; Embryology; Infertility; Metabolomics;
D O I
10.1007/s00129-014-3327-y
中图分类号
学科分类号
摘要
Topics of gynecological endocrinology and reproductive medicine have an impact on many areas in gynecological daily activities. Therefore, in this article we have selected two special issues out of this broad field as examples: recurrent miscarriages are elucidated regarding the evidence-based diagnostic work-up in order to provide a sustainable basis for patient consultation. Regarding reproductive medicine, we have concentrated on new assessment procedures for the developmental potential of embryos in vitro. Even though the pregnancy rates in artificial reproductive techniques have improved within the last 30 years, particularly due to the transfer of blastocysts, they remain below a maximum of 50 %. Therefore, evaluation of germ cell and embryo competence by non-invasive tools is of utmost interest. For non-invasive diagnostics of embryonic developmental ability of the ovum and embryo research focuses on cumulus cells, secretory products of embryo culture and the morphokinetics of embryos. © 2014, Springer-Verlag Berlin Heidelberg.
引用
收藏
页码:627 / 633
页数:6
相关论文
共 26 条
[1]  
Definitions of infertility and recurrent pregnancy loss, Fertil Steril, 90, 5, (2008)
[2]  
Assou S., Haouzi D., De Vos J., Human cumulus cells as biomarkers for embryo and pregnancy outcomes, Mol Hum Reprod, 16, pp. 531-538, (2010)
[3]  
Boots C., Stephenson M.D., Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review, Semin Reprod Med, 29, 6, pp. 507-513, (2011)
[4]  
Botros L., Sakkas D., Metabolomics and its application for non-invasive embryo assessment in IVF, Mol Hum Reprod, 14, pp. 679-690, (2008)
[5]  
Budenhofer B.K., Thyroid (dys-)function in normal and disturbed pregnancy, Arch Gynecol Obstet, 287, 1, pp. 1-7, (2013)
[6]  
Campbell A., Fishel S., Bowmann N., Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics, Reprod Biomed Online, 26, pp. 477-485, (2013)
[7]  
Campbell A., Fishel S., Bowmann N., Retrospective analysis of outcomes after IVF using an aneuploidy risk model derived from time-lapse imaging without PGS, Reprod Biomed Online, 27, pp. 140-146, (2013)
[8]  
Carrington B., Sacks G., Regan L., Recurrent miscarriage: pathophysiology and outcome, Curr Opin Obstet Gynecol, 17, 6, pp. 591-597, (2005)
[9]  
Chavez S.L., Loewke K.E., Han J., Dynamic behavior reflects human embryo ploidy by the four-cell stage, Nat Commun, 3, (2012)
[10]  
Davies S., Christopikou D., Tsorva E., Delayed cleavage division and a prolonged transition between 2- and 4-cell stages in embryos identified as aneuploidy at the 8-cell stage by array-CGH, Hum Reprod 27(Suppl 2):ii84–ii86, (2012)