Multisystem Langerhans Cell Histiocytosis in ChildrenCurrent Treatment and Future Directions

被引:0
作者
Milen Minkov
机构
[1] St Anna Children’s Hospital,Department of Outpatient Hematology Oncology
来源
Pediatric Drugs | 2011年 / 13卷
关键词
Etoposide; Hematopoietic Stem Cell Transplantation; Vinblastine; Cladribine; Disease Reactivation;
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学科分类号
摘要
Langerhans cell histiocytosis (LCH) is a rare (about 3–5 cases per million children aged 0–14 years), non-malignant disease characterized by proliferation and accumulation of clonal dendritic cells, extreme clinical heterogeneity, and an unpredictable course. Three large-scale, international, prospective therapeutic studies (LCH-I to III) for multisystem LCH (MS-LCH) have been conducted by the Histiocyte Society since 1991. The cumulative lessons from these studies are summarized in this review.
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页码:75 / 86
页数:11
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