共 435 条
[1]
Reiman EM(2010)Alzheimer’s prevention initiative: a proposal to evaluate presymptomatic treatments as quickly as possible Biomark Med 4 3-14
[2]
Langbaum JBS(2014)The A4 study: stopping AD before symptoms begin? Sci Transl Med 19 228fs13-264
[3]
Tariot PN(2010)Alzheimer’s Disease Neuroimaging Initiative. The Alzheimer’s Disease Neuroimaging Initiative: annual change in biomarkers and clinical outcomes Alzheimers Dement 6 257-397
[4]
Sperling RA(2009)Current Alzheimer's disease clinical trials: methods and placebo outcomes Alzheimers Dement 5 388-283
[5]
Rentz DM(2014)Clinical trials and late-stage drug development for Alzheimer’s disease: an appraisal from 1984 to 2014 J Intern Med 275 251-1606
[6]
Johnson KA(2012)Measuring clinical progression in MCI and pre-MCI populations: enrichment and optimizing clinical outcomes over time Alzheimers Res Ther 4 24-405
[7]
Karlawish J(2012)Incidence of mild cognitive impairment in the Pittsburgh cardiovascular health study-cognition study Neurology 79 1599-316
[8]
Donohue M(2017)Progression from normal cognition to mild cognitive impairment in a diverse clinic-based and community-based elderly cohort Alzheimers Dement 13 399-1171
[9]
Salmon DP(2004)Evidentiary standards for drug development and approval NeuroRx 1 307-674
[10]
Aisen P(2013)Regulatory innovation and drug development for early-stage Alzheimer’s disease N Engl J Med 368 1169-970