Development of orodispersible tablets of taste masked rizatriptan benzoate using hydroxypropyl β cyclodextrin

被引：14
作者：
Dungarwal U.N. [1 ]
Patil S.B. [1 ]
机构：
[1] Shri Neminath Jain Brahmacharyashram’s, Shriman Sureshdada Jain College of Pharmacy (PG Course), Neminagar, Chandwad, Dist., Nashik, 423 101, Maharashtra
来源：
Journal of Pharmaceutical Investigation | 2016年 / 46卷 / 6期
关键词：
Hydroxypropyl; β; cyclodextrin; Inclusion complex; Orodispersible tablets; Rizatriptan benzoate; Superdisintegrant; Taste masking;
D O I：
10.1007/s40005-016-0240-5
中图分类号：
学科分类号：
摘要：
The objective of the present study was to prepare orodispersible tablets of rizatriptan benzoate using hydroxypropyl β cyclodextrin (HPβCD) to mask the bitter taste. Taste-masked complex of rizatriptan was prepared with HPβCD by kneading, and analyzed for drug content, FTIR, DSC and bitterness test. Tablets were prepared by direct compression using crospovidone as superdisintegrant. The tablets were evaluated for weight variation, mechanical strength, in vitro disintegration time, wetting time, water absorption ratio, and in vitro release characteristics. The complex showed effective taste masking as compared to plain drug. Hardness and friability data indicated good mechanical strength of tablets. The tablets dispersed rapidly in 35 to 71 s with faster release rate of rizatriptan benzoate. The stability studies for 3 months showed no significant changes in quality of tablets. Hence the present studies indicated the abilities of HPβCD for taste masking and improving the dissolution profile of rizatriptan benzoate after complexation. © 2016, The Korean Society of Pharmaceutical Sciences and Technology.
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页码：537 / 545
页数：8
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共 30 条
  • [1] Albertini B., Cavallari C., Passerini N., Voinovich D., Rodriguez M.L., Magarotto L., Rodriguez L., Characterization and taste masking evaluation of acetaminophen granules: comparison between different preparation methods in a high shear mixer, Eur J Pharm Sci, 21, pp. 295-303, (2004)
  • [2] Ammar H.O., Salama H.A., Ghorab M., Mahmoud A.A., Implication of inclusion complexation of glimepiride in cyclodextrin–polymer systems on its dissolution, stability and therapeutic efficacy, Int J Pharm, 320, pp. 53-57, (2006)
  • [3] Bi Y., Sunada H., Yonezawa Y., Danjo K., Lida K., Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity, Chem Pharm Bull, 44, pp. 2121-2127, (1996)
  • [4] Chang R.K., Guo X., Burnside B.A., Couch R.A., Fast dissolving tablets, Pharm Technol, 246, pp. 52-58, (2000)
  • [5] Chaudhari P.D., Chaudhari S.P., Kolhe S.R., Dave K.V., More D.M., Formulation and evaluation of fast dissolving tablets of famotidine, Indian Drugs, 42, pp. 641-649, (2005)
  • [6] Corveleyn S., Remon J.P., Formulation and production of rapidly disintegrating tablets by lyophilization using hydrochlorothiazide as a model drug, Int J Pharm, 152, pp. 215-225, (1997)
  • [7] Gao Y., Cui F., Guan Y., Yang L., Wang Y., Zhang L., Preparation of roxithromycin-polymeric microspheres by the emulsion solvent diffusion method for taste masking, Int J Pharm, 318, pp. 62-69, (2006)
  • [8] Gohel M.C., Patel M., Amin A., Agrawal R., Dave R., Bariya N., Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique, AAPS Pharm Sci Tech, 5, 36, pp. 1-6, (2004)
  • [9] Gohel M.C., Parikh R.K., Brahmbhatt B.K., Shah A.R., Improving the tablet characteristics and dissolution profile of ibuprofen by using a novel coprocessed superdisintegrant: a technical note, AAPS Pharm Sci Tech 8(13):E1E6, (2007)
  • [10] Gosai A.R., Patil S.B., Sawant K.K., Formulation and evaluation of orodispersible tablets of ondansetron hydrochloride by direct compression using superdisintegrants, Int J Pharm Sci Nanotech, 1, 1, pp. 104-111, (2008)
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