A microemulsion-based hydrogel formulation containing voriconazole for topical skin delivery

被引：6

作者：

Kim Y.-H. ^{[1
]}

Song C.K. ^{[1
]}

Jung E. ^{[1
]}

Kim D.-H. ^{[1
]}

Kim D.-D. ^{[1
]}

机构：

[1] College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul

来源：

Journal of Pharmaceutical Investigation | 2014年 / 44卷 / 7期

基金：

新加坡国家研究基金会;

关键词：

Hydrogel; Microemulsion; Skin; Topical delivery; Voriconazole;

D O I：

10.1007/s40005-014-0159-7

中图分类号：

学科分类号：

摘要：

Microemulsion-based hydrogels (MBHs) containing voriconazole were prepared as a possible topical delivery system for enhancing drug absorption at the site of action, as well as reducing the frequency of systemic side effects. Microemulsions were prepared with N-methyl-2-pyrrolidone as a surfactant, benzyl alcohol as an oil, and an ethanol/phosphatidylcholine mixture (3:2, w/w) as a cosurfactant. MBHs were prepared by adding carbopol 940 or xanthan gum as a gelling agent. In vitro skin permeation and deposition studies were performed using static vertical diffusion Franz cells and hairless mouse skin. The in vitro permeation data showed that the optimized microemulsion formulations consisting of voriconazole (1 %, w/w) and benzyl alcohol (10 %, w/w) showed significantly higher drug permeation rates and skin deposition compared to propylene glycol (control). However, the addition of a gelling agent did not significantly change the permeation profiles compared to the microemulsions. In vivo skin deposition studies conducted on hairless mice with MBHs also confirmed the superiority of MBHs compared to the control. These results suggested the MBH system to be a promising vehicle for topical delivery of voriconazole. © 2014, The Korean Society of Pharmaceutical Sciences and Technology.

引用

页码：517 / 524

页数：7

共 27 条

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