Ionic liquid-phase organic synthesis (IoLiPOS) methodology applied to cross aldol reaction

被引：0

作者：

H. Hakkou

D. Carrié

L. Paquin

J. -P. Bazureau

机构：

[1] Université de Rennes 1,Laboratoire Sciences Chimiques de Rennes, UMR CNRS 6226, Groupe Ingénierie Chimique & Molécules pour le Vivant (ICMV), Bât. 10A, Campus de Beaulieu

来源：

Russian Journal of Organic Chemistry | 2011年 / 47卷

关键词：

Ionic Liquid; Aldol; Cyclopentanone; Aldol Reaction; MeONa;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Cross aldol reaction in task-specific ionic liquids was developed. Ionic liquid-phase bound aldehyde reacted with various ketones (acetone, cyclopentanone, and butan-2-one) with l-proline as catalyst to afford various ionic liquid-phase supported aldols in yields ranging from 81 to 99%. Detachment of the aldol in MeOH was realized by transesterification using 15% of MeONa. The structure of intermediates in each step was verified by spectroscopic analysis.

引用

页码：371 / 373

页数：2

共 35 条

[1]

Eder U.(1971)undefined Angew. Chem., Int. Ed. Engl. 10 496-undefined

[2]

Sauer G.(2001)undefined J. Am. Chem. Soc. 123 5260-undefined

[3]

Wieckert R.(2006)undefined Chem. Eur. J. 12 5383-undefined

[4]

Sakthivel K.(2002)undefined Org. Proc. Res. Dev. 6 374-undefined

[5]

Notz W.(2001)undefined Tetrahedron Lett. 42 6097-undefined

[6]

Bui T.(2006)undefined Acc. Chem. Res. 39 897-undefined

[7]

Barbas C.F.(2007)undefined Org. Lett. 9 2681-undefined

[8]

Cordova A.(2008)undefined Tetrahedron 64 5328-undefined

[9]

Zou W.(2002)undefined Tetrahedron Lett. 43 8741-undefined

[10]

Dziedzic P.(2004)undefined Acc. Chem. Res. 37 487-undefined

← 1 2 3 4 →