Transcriptomic studies of systemic lupus erythematosus

被引:0
作者
Masahiro Nakano
Yukiko Iwasaki
Keishi Fujio
机构
[1] The University of Tokyo,Department of Allergy and Rheumatology, Graduate School of Medicine
来源
Inflammation and Regeneration | / 41卷
关键词
Systemic lupus erythematosus; Lupus nephritis; Transcriptome; Review;
D O I
暂无
中图分类号
学科分类号
摘要
The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and treatment strategies for SLE, previous microarray and RNA sequencing studies have demonstrated several disease-relevant signatures in SLE. Of these, the interferon (IFN) signature is complex, involving IFNβ- and IFNγ-response genes in addition to IFNα-response genes. Some studies revealed that myeloid lineage/neutrophil and plasma cell signatures as well as the IFN signature were correlated with disease activity, lupus nephritis, and complications of pregnancy, although some of these findings remain controversial. Cell-type-specific gene expression analysis revealed the importance of an exhaustion signature in CD8+ T cells for SLE outcome. Recent single-cell RNA sequencing analyses of SLE blood and tissues demonstrated molecular heterogeneity and identified several distinct subpopulations as key players in SLE pathogenesis. Further studies are required to identify novel treatment targets and determine precise patient stratification in SLE. In this review, we discuss the findings and limitations of SLE transcriptomic studies.
引用
收藏
相关论文
共 50 条
  • [41] Complement as a Biomarker for Systemic Lupus Erythematosus
    Ayano, Masahiro
    Horiuchi, Takahiko
    BIOMOLECULES, 2023, 13 (02)
  • [42] Genetics and systemic lupus erythematosus.
    Tsao B.P.
    Grossman J.M.
    Current Rheumatology Reports, 2001, 3 (3) : 183 - 190
  • [43] Silent nephritis in systemic lupus erythematosus
    Zabaleta-Lanz, M
    Vargas-Arenas, RE
    Tápanes, F
    Daboin, I
    Pinto, JA
    Bianco, NE
    LUPUS, 2003, 12 (01) : 26 - 30
  • [44] Systemic lupus erythematosus and "lupus dyslipoproteinemia"
    de Carvalho, Jozelio Freire
    Bonfa, Eloisa
    Borba, Eduardo Ferreira
    AUTOIMMUNITY REVIEWS, 2008, 7 (03) : 246 - 250
  • [45] Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states
    Wang, Frank Qingyun
    Shao, Li
    Dang, Xiao
    Wang, Yong-Fei
    Chen, Shuxiong
    Liu, Zhongyi
    Mao, Yujing
    Jiang, Yuping
    Hou, Fei
    Guo, Xianghua
    Li, Jian
    Zhang, Lili
    Sang, Yuting
    Zhao, Xuan
    Ma, Ruirui
    Zhang, Kai
    Zhang, Yanfang
    Yang, Jing
    Wen, Xiwu
    Liu, Jiong
    Wei, Wei
    Zhang, Chuanpeng
    Li, Weiyang
    Qin, Xiao
    Lei, Yao
    Feng, Hong
    Yang, Xingtian
    She, Chun Hing
    Zhang, Caicai
    Su, Huidong
    Chen, Xinxin
    Yang, Jing
    Lau, Yu Lung
    Wu, Qingjun
    Ban, Bo
    Song, Qin
    Yang, Wanling
    ARTHRITIS RESEARCH & THERAPY, 2024, 26 (01)
  • [46] Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus
    Mistry, Pragnesh
    Nakabo, Shuichiro
    O'Neil, Liam
    Goel, Rishi R.
    Jiang, Kan
    Carmona-Rivera, Carmelo
    Gupta, Sarthak
    Chan, Diana W.
    Carlucci, Philip M.
    Wang, Xinghao
    Naz, Faiza
    Manna, Zerai
    Dey, Amit
    Mehta, Nehal N.
    Hasni, Sarfaraz
    Dell'Orso, Stefania
    Gutierrez-Cruz, Gustavo
    Sun, Hong-Wei
    Kaplan, Mariana J.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (50) : 25222 - 25228
  • [47] Progress of rituximab in the treatment of systemic lupus erythematosus and lupus nephritis
    Mo, Shouqi
    Li, Yilan
    He, Junbing
    Lin, Ling
    FRONTIERS IN MEDICINE, 2024, 11
  • [48] Cyclosporine for the treatment of lupus nephritis in patients with systemic lupus erythematosus
    Yang, Tzu-Han
    Wu, Tsai-Hung
    Chang, Yuh-Lih
    Liao, Hsien-Tzung
    Hsu, Chia-Chen
    Tsai, Chang-Youh
    Chou, Yueh-Ching
    CLINICAL NEPHROLOGY, 2018, 89 (04) : 277 - 285
  • [49] Lupus nephritis prolongs improvement of serositis in systemic lupus erythematosus
    Harada, Takuya
    Yamashita, Hiroyuki
    Nakajima, Sotaro
    Kobayashi, Toshiaki
    Takahashi, Hiroyuki
    Kaneko, Hiroshi
    JOINT BONE SPINE, 2024, 91 (04)
  • [50] Genetic Factors Predisposing to Systemic Lupus Erythematosus and Lupus Nephritis
    Ramos, Paula S.
    Brown, Elisabeth E.
    Kimberly, Robert P.
    Langefeld, Carl D.
    SEMINARS IN NEPHROLOGY, 2010, 30 (02) : 164 - 176