Integration of Translational Research in the European Organization for Research and Treatment of Cancer Research (EORTC) Clinical Trial Cooperative Group Mechanisms

被引：20

作者：

Frederic Lehmann

Denis Lacombe

Patrick Therasse

Alexander MM Eggermont

机构：

[1] EORTC Data Center,Erasmus MC – Daniel den Hoed Cancer Center

[2] Dept of Surgical Oncology,undefined

来源：

Journal of Translational Medicine | / 1卷 / 1期

关键词：

Translational Research; Early Clinical Trial; Clinical Trial Network; Translational Research Project; Translational Research Study;

D O I：

10.1186/1479-5876-1-2

中图分类号：

学科分类号：

摘要：

The landscape for cancer research is profoundly different today from that only one decade ago. Basic science is moving rapidly and biotechnological revolutions in molecular targeting and immunology have completely modified the opportunities and concepts for cancer treatment. In contrast to the recent past where cytotoxic molecules were screened in the laboratory and then tested in early clinical studies with toxicity as endpoint instead of the often poorly defined mechanism for its potential anti-tumor effect, we now have entered the age of molecular therapeutics, rationally designed to target "strategic" checkpoints that underlie the malignant phenotype.

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