Exosomes: Promising Delivery Tools for Overcoming Blood-Brain Barrier and Glioblastoma Therapy

被引：0

作者：

Seyyed Hossein Khatami

Neda Karami

Mortaza Taheri-Anganeh

Sina Taghvimi

Gholamhossein Tondro

Marjan Khorsand

Elahe Soltani Fard

Najmeh Sedighimehr

Marzieh Kazemi

Khojaste Rahimi Jaberi

Melika Moradi

Parvaneh Nafisi Fard

Mohammad Hasan Darvishi

Ahmad Movahedpour

机构：

[1] Shahid Beheshti University of Medical Sciences,Department of Clinical Biochemistry, School of Medicine

[2] TU Wien,Cellular and Molecular Research Center

[3] Institute of Solid State Electronics,Department of Biology, Faculty of Science

[4] Cellular and Molecular Medicine Research Institute,Microbiology Department, Faculty of Medicine

[5] Urmia University of Medical Sciences,Department of Biochemistry

[6] Shahid Chamran University of Ahvaz,Department of Molecular Medicine, School of Advanced Technologies

[7] AJA University of Medical Sciences,Department of Physical Therapy, School of Rehabilitation

[8] School of Medicine,Department of Radio

[9] Shiraz University of Medical Sciences,oncology, Namazi Teaching Hospital

[10] Shahrekord University of Medical Sciences,Department of Neuroscience, School of Advanced Medical Sciences and Technologies

[11] Shiraz University of Medical Sciences,Department of Microbiology, School of Medicine

[12] Shiraz University of Medical Sciences,Department of Veterinary Clinical Science, Faculty of Veterinary Medicine

[13] Shiraz University of Medical Sciences,Nanobiotechnology Research Center

[14] Ahvaz Jundishapur University of Medical Sciences,undefined

[15] Ferdowsi University of Mashhad,undefined

[16] Baqiyatallah University of Medical Sciences,undefined

[17] Behbahan Faculty of Medical Sciences,undefined

来源：

Molecular Neurobiology | 2023年 / 60卷

关键词：

Glioblastoma; Blood-brain barrier; Drug delivery; Exosomes;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis despite the ongoing advances in treatment modalities. One of the main reasons for this shortcoming is the presence of the blood-brain barrier and blood-brain tumor barrier. Novel invasive and non-invasive drug delivery strategies for glioblastoma have been developed to overcome both the intact blood-brain barrier and leverage the disrupted nature of the blood-brain tumor barrier to target cancer cells after resection—the first treatment stage of glioblastoma. Exosomes are among non-invasive drug delivery methods and have emerged as a natural drug delivery vehicle with high biological barrier penetrability. There are various exosome isolation methods from different origins, and the intended use of the exosomes and starting materials defines the choice of isolation technique. In the present review, we have given an overview of the structure of the blood-brain barrier and its disruption in glioblastoma. This review provided a comprehensive insight into novel passive and active drug delivery techniques to overcome the blood-brain barrier, emphasizing exosomes as an excellent emerging drug, gene, and effective molecule delivery vehicle used in glioblastoma therapy.

引用

页码：4659 / 4678

页数：19

共 721 条

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