Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity relationships

被引：0

作者：

Ki -Jun Hwang

Kyung -Ho Park

Chong -Ock Lee

Beom -Tae Kim

机构：

[1] Chonbuk National University,Department of Chemistry and Research Center of Bioactive Materials, College of Natural Science

[2] Experimental Station,Dupont CR&D

[3] Korea Research Institute of Chemical Technology,Screening & Toxicology Research Center

[4] Chonbuk National University,Department of Chemistry, College of Natural Science

来源：

Archives of Pharmacal Research | 2002年 / 25卷

关键词：

Benzoyl Urea; Anticancer; Cisplatin; Cytotoxicity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50~100 times greater antitumor activities than the commercial product, Cisplatin.

引用

页码：781 / 785

页数：4

共 50 条

[21] Synthesis, Antifungal, and Antibacterial Activities of Novel Benzoylurea Derivatives Containing a Pyrimidine Moiety
An, Jiansong
Lan, Wenjun
Fei, Qiang
Li, Pei
Wu, Wenneng
MOLECULES, 2023, 28 (18):
[22] Synthesis, structure-activity relationships studies of benzoxazinone derivatives as α-chymotrypsin inhibitors
Marasini, Bishnu P.
Rahim, Fazal
Perveen, Shahnaz
Karim, Aneela
Khan, Khalid Mohammed
Atta-ur-Rahman
Choudhary, M. Iqbal
BIOORGANIC CHEMISTRY, 2017, 70 : 210 - 221
[23] Antitumor agents 251: Synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents
Wei, Linyi
Brossi, Arnold
Kendall, Ross
Bastow, Kenneth F.
Morris-Natschke, Susan L.
Shi, Qian
Lee, Kuo-Hsiung
BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (19) : 6560 - 6569
[24] Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel tri-substituted thiazole derivatives
Reddy, Guda Mallikarjuna
Garcia, Jarem Raul
Reddy, Vemulapati Hanuman
de Andrade, Ageo Meier
Camilo, Alexandre, Jr.
Pontes Ribeiro, Renan Augusto
de lazaro, Sergio Ricardo
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 123 : 508 - 513
[25] Piperine and Derivatives: Trends in Structure-Activity Relationships
Singh, Inder Pal
Choudhary, Alka
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2015, 15 (17) : 1722 - 1734
[26] Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents
Hisham, Mohamed
Youssif, Bahaa G. M.
Osman, Essam Eldin A.
Hayallah, Alaa M.
Abdel-Aziz, Mohamed
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 176 : 117 - 128
[27] Synthesis and antiproliferative activities of novel piscidinol a derivatives as potential anticancer agents
Gaja, Swarna Kumari
Bandi, Siva
Pavuluri, Pavan Kumar
Sambyal, Shainy
Jaina, Vinod Kumar
Kumar, H. M. Sampath
Andugulapati, Sai Balaji
Ramalingam, V
Babu, K. Suresh
NATURAL PRODUCT RESEARCH, 2023, 37 (15) : 2568 - 2574
[28] Simple and efficient synthesis of novel glycosyl thiourea derivatives as potential antitumor agents
Zhang Shusheng
Zhan Tianrong
Cheng Kun
Xia Youfeng
Yang Bo
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (12) : 2778 - 2783
[29] Synthesis and structure-activity studies of antofine analogues as potential anticancer agents
Fu, Ye
Lee, Sang Kook
Min, Hye-Young
Lee, Taeho
Lee, Jaekwang
Cheng, Maosheng
Kim, Sanghee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (01) : 97 - 100
[30] Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships
Suzuki, K
Okawara, T
Higashijima, T
Yokomizo, K
Mizushima, T
Otsuka, M
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (08) : 2065 - 2068

← 1 2 3 4 5 →