Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity relationships

被引：0
作者：
Ki -Jun Hwang
Kyung -Ho Park
Chong -Ock Lee
Beom -Tae Kim
机构：
[1] Chonbuk National University,Department of Chemistry and Research Center of Bioactive Materials, College of Natural Science
[2] Experimental Station,Dupont CR&D
[3] Korea Research Institute of Chemical Technology,Screening & Toxicology Research Center
[4] Chonbuk National University,Department of Chemistry, College of Natural Science
来源：
Archives of Pharmacal Research | 2002年 / 25卷
关键词：
Benzoyl Urea; Anticancer; Cisplatin; Cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50~100 times greater antitumor activities than the commercial product, Cisplatin.
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页码：781 / 785
页数：4
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