Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity relationships

被引：0

作者：

Ki -Jun Hwang

Kyung -Ho Park

Chong -Ock Lee

Beom -Tae Kim

机构：

[1] Chonbuk National University,Department of Chemistry and Research Center of Bioactive Materials, College of Natural Science

[2] Experimental Station,Dupont CR&D

[3] Korea Research Institute of Chemical Technology,Screening & Toxicology Research Center

[4] Chonbuk National University,Department of Chemistry, College of Natural Science

来源：

Archives of Pharmacal Research | 2002年 / 25卷

关键词：

Benzoyl Urea; Anticancer; Cisplatin; Cytotoxicity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50~100 times greater antitumor activities than the commercial product, Cisplatin.

引用

页码：781 / 785

页数：4

共 50 条

[1] Novel benzoylurea derivatives as potential antitumor agents; Synthesis, activities and structure-activity relationships
Hwang, KJ
Park, KH
Lee, CO
Kim, BT
ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (06) : 781 - 785
[2] Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents
Song, Dan-Qing
Wang, Yue-Ming
Du, Na-Na
He, Wei-Ying
Chen, Ke-Liang
Wang, Gui-Fang
Yang, Peng
Wu, Lian-Zong
Zhang, Xue-Bo
Jiang, Jian-Dong
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (03) : 755 - 758
[3] Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives
Srivastava, Sanjay K.
Jha, Amrita
Agarwal, Shiv K.
Mukherjee, Rama
Burman, Anand C.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2007, 7 (06) : 685 - 709
[4] Design, Synthesis and Structure-Activity Relationships of Novel Diaryl Urea Derivatives as Potential EGFR Inhibitors
Jiang, Nan
Bu, Yanxin
Wang, Yu
Nie, Minhua
Zhang, Dajun
Zhai, Xin
MOLECULES, 2016, 21 (11)
[5] Synthesis and structure-activity relationships of sinenxan A derivatives as multidrug resistance reversal agents
Huang, Meng
Zhao, Xin
Zhang, Meng
Gu, Jun
Chen, Xiaoguang
Yin, Dali
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (18) : 5418 - 5421
[6] Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents
Milelli, Andrea
Tumiatti, Vincenzo
Micco, Marialuisa
Rosini, Michela
Zuccari, Guendalina
Raffaghello, Lizzia
Bianchi, Giovanna
Pistoia, Vito
Fernando Diaz, J.
Pera, Benet
Trigili, Chiara
Barasoain, Isabel
Musetti, Caterina
Toniolo, Marianna
Sissi, Claudia
Alcaro, Stefano
Moraca, Federica
Zini, Maddalena
Stefanelli, Claudio
Minarini, Anna
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 57 : 417 - 428
[7] Preparation and structure-activity relationships of novel asterriquinone derivatives
Kaji, A
Kimura, K
Teranishi, M
Kiriyama, N
Nomura, M
Miyamoto, K
CHEMICAL & PHARMACEUTICAL BULLETIN, 1998, 46 (08) : 1325 - 1329
[8] Design, synthesis, biological evaluation and structure-activity relationship of sophoridine derivatives bearing pyrrole or indole scaffold as potential antitumor agents
Li, Zheng
Luo, Mengyang
Cai, Bin
Haroon-Ur-Rashid
Huang, Mengtian
Jiang, Jun
Wang, Lisheng
Wu, Lichuan
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 157 : 665 - 682
[9] Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents
Cheng, Wei-Hua
Cao, Bo
Shang, Hai
Niu, Cong
Zhang, Li-Ming
Zhang, Zhong-Heng
Tian, Dan-Li
Zhang, Shi
Chen, Hong
Zou, Zhong-Mei
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 85 : 498 - 507
[10] Synthesis and Biological Activity of Anthrapyrazoles Derivatives as Potential Antitumor Agents
Wang, Jianhong
Zhao, Huijun
Luo, Zhaoyang
Wang, Zhaoyi
Zhang, Yahong
Zhao, Jin
MEDICINAL CHEMISTRY, 2014, 10 (08) : 772 - 777

← 1 2 3 4 5 →