The threat of avian influenza A (H5N1). Part IV: development of vaccines

被引：0
作者：
Jindrich Cinatl jr
Martin Michaelis
Hans W. Doerr
机构：
[1] Hospital of the Johann Wolfgang Goethe University,Institute for Medical Virology
来源：
Medical Microbiology and Immunology | 2007年 / 196卷
关键词：
Influenza; Influenza Virus; Influenza Vaccine; H5N1 Virus; Avian Influenza Virus;
D O I：
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中图分类号：
学科分类号：
摘要：
Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This fourth part focuses on vaccine development. Several phase I clinical studies with vaccines against H5 viruses have demonstrated limited efficacy compared to seasonal influenza vaccines. To induce protective immunity two immunisations with increased amounts of H5N1 vaccine were required. Novel vaccination strategies that are egg- and adjuvant-independent, broadly cross-reactive and long-lasting are highly desirable.
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页码：213 / 225
页数：12
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