Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

被引：96

作者：

Crawley, Jacqueline N. ^{[1
,2
]}

Heyer, Wolf-Dietrich ^{[3
,4
]}

LaSalle, Janine M. ^{[1
,5
,6
]}

机构：

[1] Univ Calif Davis, Sch Med, MIND Inst, Sacramento, CA 95817 USA

[2] Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA

[3] Univ Calif Davis, Dept Microbiol & Mol Genet, Davis, CA 95616 USA

[4] Univ Calif Davis, Ctr Comprehens Canc, Sacramento, CA 95817 USA

[5] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

[6] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

来源：

TRENDS IN GENETICS | 2016年 / 32卷 / 03期

关键词：

SPECTRUM DISORDER;

D O I：

10.1016/j.tig.2016.01.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.

引用

页码：139 / 146

页数：8

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