Increased Prevalence of Hepatic Steatosis in Young Adults With Lifelong HIV

被引：24

作者：

Aepfelbacher, Julia A. ^{[1
]}

Balmaceda, Julia ^{[1
]}

Purdy, Julia ^{[2
]}

Mattingly, Aviva ^{[1
]}

Zambell, Kirsten ^{[3
]}

Hawkins, Karyn ^{[4
]}

Chairez, Cheryl ^{[1
]}

Curl, Kara Anne ^{[1
]}

Dee, Nicola ^{[1
]}

Hadigan, Colleen ^{[1
]}

机构：

[1] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NIH, Dept Crit Care Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[3] NIH, Dept Nutr, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[4] NIH, Dept Nursing, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 220卷 / 02期

关键词：

HIV; AIDS; hepatic steatosis; nonalcoholic fatty liver disease; young adults; LIVER-DISEASE; FATTY LIVER; TRANSIENT ELASTOGRAPHY; PROGNOSIS; FIBROSIS; RISK;

D O I：

10.1093/infdis/jiz096

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Little is known about the effects of lifelong human immunodeficiency virus (HIV) or antiretroviral therapy on hepatic steatosis and fibrosis. Using transient elastography, we evaluated 46 young adults with lifelong HIV and 20 matched HIV-negative controls. Steatosis was present in 33% of persons with HIV and only 10% of controls (P = .04). Hepatic fibrosis scores were not elevated and did not differ between groups. Metabolic parameters, particularly increased waist circumference, and not HIV-specific factors, were significantly associated with steatosis. While this finding should be examined in larger cohorts, modifiable metabolic disturbances may be important targets to optimize liver health in this population.

引用

页码：266 / 269

页数：4

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