Anti-prion antibodies for prophylaxis following prion exposure in mice

被引：86

作者：

Sigurdsson, EM

Sy, MS

Li, RL

Scholtzova, H

Kascsak, RJ

Kascsak, R

Carp, R

Meeker, HC

Frangione, B

Wisniewski, T

机构：

[1] NYU, Sch Med, Dept Psychiat, Millhauser lab, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pathol, Millhauser lab, New York, NY 10016 USA

[3] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[4] NYU, Sch Med, Dept Neurol, Millhauser Lab, New York, NY 10016 USA

[5] New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA

来源：

NEUROSCIENCE LETTERS | 2003年 / 336卷 / 03期

关键词：

prion; vaccination; treatment; antibodies; passive immunization;

D O I：

10.1016/S0304-3940(02)01192-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prion disease is characterized by a conformational change of the normal form of the prion protein (PrPc) to the scrapie-associated form (PrPSc). Since the emergence of new variant Creutzfeldt-Jakob disease a potentially large human population is at risk for developing prion disease. Currently, no effective treatment or form of post-exposure prophylaxis is available for prion disease. We recently showed that active immunization with recombinant PrP prolongs the incubation period of scrapie. Here we show that anti-PrP antibodies following prion exposure are effective at increasing the incubation period of the infection. Stimulation of the immune system is an important therapeutic target for the prion diseases, as well as for other neurodegenerative illnesses characterized by abnormal protein conformation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：185 / 187

页数：3

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