Perioperative management of tumor necrosis factor-alpha blocker-treated psoriatic patients: Case reports and review

被引：9

作者：

Kawakami, Hiroshi ^{[1
]}

Matsumoto, Yuka ^{[1
]}

Abe, Namiko ^{[1
]}

Katori, Youich ^{[2
]}

Takahashi, Kousuke ^{[3
]}

Tsuboi, Ryoji ^{[1
]}

Okubo, Yukari ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Dermatol, Tokyo 1608402, Japan

[2] Tokyo Med Univ, Dept Orthoped, Tokyo 1608402, Japan

[3] Tokyo Med Univ, Dept Surg Gastroenterol, Tokyo 1608402, Japan

来源：

JOURNAL OF DERMATOLOGY | 2016年 / 43卷 / 02期

关键词：

adalimumab; biologics; elective surgery; infliximab; methotrexate; tumor necrosis factor-alpha blockers; RHEUMATOID-ARTHRITIS; COMPLICATIONS; METHOTREXATE; SURGERY;

D O I：

10.1111/1346-8138.13047

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Regarding appropriate timings of discontinuation and resumption of biologics for psoriasis patients before and after elective surgeries, an international consensus has yet to be reached. The Japanese Dermatological Association of Guideline and Safety Manual for the use of Biologic Agents in Psoriasis 2013 states that infliximab (IFX) and adalimumab (ADA) should be withheld at least 4 and 2weeks, respectively, before surgery and can be restarted as neither postoperative infection nor delayed wound healing is recognized. We experienced three generalized pustular psoriasis (GPP) patients and one plaque-type psoriasis patient undergoing surgeries during tumor necrosis factor (TNF)- blocker therapy. Three GPP cases experienced uneventful post-surgical course. One psoriasis vulgaris patient on IFX had a wound healing delay with deterioration of psoriatic plaques which was restored by restarting IFX. The timing of suspension and resumption of TNF- blockers in all cases were determined following the Japanese guideline.

引用

页码：190 / 193

页数：4

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