PFAS exposure and overweight/obesity among children in a nationally representative sample

被引:78
作者
Geiger, Sarah Dee [1 ,2 ]
Yao, Ping [3 ]
Vaughn, Michael G. [4 ]
Qian, Zhengmin [5 ]
机构
[1] Univ Illinois, Coll Appl Hlth Sci, Dept Kinesiol & Community Hlth, Urbana, IL 61820 USA
[2] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
[3] Northern Illinois Univ, Sch Hlth Studies, De Kalb, IL USA
[4] St Louis Univ, Sch Social Work, Coll Publ Hlth & Social Justice, Tegeler Hall,3550 Lindell Blvd, St Louis, MO 63103 USA
[5] St Louis Univ, Dept Epidemiol & Biostat, Coll Publ Hlth & Social Justice, 3545 Lafayette Ave, St Louis, MO 63104 USA
关键词
NUTRITION EXAMINATION SURVEY; URINARY BISPHENOL-A; PERFLUORINATED CHEMICALS; CHILDHOOD OVERWEIGHT; PRENATAL EXPOSURES; FETAL-GROWTH; ASSOCIATION; OBESITY; HEALTH; PFOA;
D O I
10.1016/j.chemosphere.2020.128852
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Purpose: Perfluoroalkyl substances (PFASs) are a class of manmade chemicals commonly used in consumer product manufacturing. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are two of the most highly studied PFASs. Both are present in the blood of the most Americans. PFASs are associated with intermediate cardiovascular disease (CVD) outcomes, but their relationship with obesity, a risk factor for intermediate and advanced CVD, remains largely unconfirmed. In this context, we aimed to explore the relationship between PFASs and both overweight/obesity and abdominal obesity among children. Methods: We examine associations between PFOA and PFOS levels, and Body Mass Index (BMI) and waist circumference (WC) in a representative sample (N = 2473) of US children, aged 12-18 years from the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey 1999-2012. Overweight/obesity is defined as age-, sex-specific BMI z-score >= 85th percentile; abdominal obesity is defined as age-, sex-specific waist circumference >= 90th percentile. Results: Associations between PFASs and anthropometric outcomes show a dose-response relationship overall. For overweight/obese BMI z-score, findings indicate OR = 1.42 and 95% CI: 0.85-2.38 for quartile 2 of PFOA exposure; OR = 2.22 (95% CI: 1.20-4.13) for quartile 3 of PFOA exposure; and OR = 2.73 (95% CI:1.10-6.74) for quartile 4 of PFOA exposure. Discussion: Findings indicate an association between elevated PFOA and overweight/obesity among children after multivariable adjustment. (C) 2020 Elsevier Ltd. All rights reserved.
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页数:5
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