Single-cell RNA Sequencing in Immunology

被引：13
|
作者：
Cao, Yirui [1 ,2 ]
Qiu, Yue [3 ]
Tu, Guowei [3 ]
Yang, Cheng [1 ,2 ,4 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Dept Urol, Shanghai 200032, Peoples R China
[2] Shanghai Key Lab Organ Transplantat, Shanghai 200032, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Crit Care Med, Shanghai 200032, Peoples R China
[4] Fudan Univ, Fudan Zhangjiang Inst, Shanghai 201203, Peoples R China
来源：
CURRENT GENOMICS | 2020年 / 21卷 / 08期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Single-cell RNA sequencing; immunology; cancer; autoimmune disease; transplantation; tumors; T-CELLS; PROTEINS; PRECURSORS; MICROGLIA; CHROMATIN; SEQ;
D O I：
10.2174/1389202921999201020203249
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The complex immune system is involved in multiple pathological processes. Single-cell RNA sequencing (scRNA-seq) is able to analyze complex cell mixtures correct to a single cell and single molecule, thus is qualified to analyze immune reactions in several diseases. In recent years, scRNA-seq has been applied in many researching fields and has presented many innovative results. In this review, we intend to provide an overview of single-cell RNA sequencing applications in immunology and a prospect of future directions.
引用
收藏
页码：564 / 575
页数：12
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