Comparison of cerebral blood volume maps generated from T2* and T1 weighted MRI data in intra-axial cerebral tumours

We compared parametric maps, measured values and value distributions of cerebral blood volume (CBV) derived from (1) first pass T-1 weighted dynamic contrast-enhanced (DCE) data (T-1-CBV) using the recently described leakage profile model and (2) conventional T-2* weighted DCE data (T-2*-CBV) using a conventional curve fitting technique, in nine patients with intraaxial tumours. Regions of interest were defined around enhancing tumour tissue on matched slices. Median tumour values and conspicuity indexes of CBV from the two techniques were compared, demonstrating good correlation (r=0.667,p<0.05) in enhancing tumour and no significant difference in conspicuity. Pixel-by-pixel scattergrams of values in normal brain in a representative matched slice were produced for each case, which showed excellent correlation (r=0.96,p<0.001). Distortion of blood vessels around susceptibility interfaces was evident on T-2* CBV but not on T-1 CBV maps. Leakage-free T-1 CBV maps do not suffer from the susceptibility artifacts seen in T-2* CBV maps, although they present comparable biological information.