TRPs in Pain Sensation

被引：104

作者：

Jardin, Isaac ^{[1
]}

Lopez, Jose J. ^{[1
]}

Diez, Raquel ^{[1
]}

Sanchez-Collado, Jose ^{[1
]}

Cantonero, Carlos ^{[1
]}

Albarran, Letizia ^{[1
]}

Woodard, Geoffrey E. ^{[2
]}

Redondo, Pedro C. ^{[1
]}

Salido, Gines M. ^{[1
]}

Smani, Tarik ^{[3
]}

Rosado, Juan A. ^{[1
]}

机构：

[1] Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Caceres, Spain

[2] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA

[3] Univ Seville, Inst Biomed Sevilla, Dept Med Physiol & Biophys, Seville, Spain

来源：

FRONTIERS IN PHYSIOLOGY | 2017年 / 8卷

关键词：

calcium entry; TRPs; TRPA1; TRPV1; noxious sensation; BONE CANCER PAIN; RECEPTOR POTENTIAL CHANNELS; ROOT GANGLION NEURONS; OPERATED CA2+ ENTRY; NEUROPATHIC PAIN; CAPSAICIN-RECEPTOR; ION-CHANNEL; VANILLOID RECEPTOR; VISCERAL PAIN; HUMAN PLATELETS;

D O I：

10.3389/fphys.2017.00392

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

According to the International Association for the Study of Pain (IASP) pain is characterized as an "unpleasant sensory and emotional experience associated with actual or potential tissue damage". The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli.

引用

页数：10

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