15N NMR spectroscopy of partially saturated pyrazoles

被引：4
|
作者：
De Benassuti, Lara [1 ]
Recca, Teresa [1 ]
Molteni, Giorgio [1 ]
机构：
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
来源：
TETRAHEDRON | 2007年 / 63卷 / 16期
关键词：
fluoroalkyl carboxylate; enzyme catalysis; esterase; assay; DAST; SOLVENT POLARITY; DERIVATIVES; SYSTEMS;
D O I：
10.1016/j.tet.2007.02.063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Partially saturated pyrazoles, namely 1-(4-substituted)phenyl-3-methoxycarbonyl-5-ethoxycarbonyl-4,5-dihydropyrazoles, were submitted to extensive (NNMR)-N-15 spectroscopic analyses, performed in natural abundance. Nitrogen chemical shifts were measured by means of INEPT and HMBC experiments, while long range proton-nitrogen scalar coupling values were taken through J-HMBC experiments. A linear plot between nitrogen chemical shifts and Hammett sigma(p) was observed, enabling us to relate quantitatively the observed chemical shifts to the electronic features of the substituent in the 1-position of the 4,5-dihydropyrazole ring. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3302 / 3305
页数：4
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