Nucleophilic 5-endo-trig cyclizations of N-homoallylic sulfonamides:: a facile method for the construction of pyrrolidine rings

被引：22

作者：

Ichikawa, Junji ^{[1
]}

Lapointe, Guillaume ^{[1
]}

Iwai, Yu ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem, Grad Sch Sci, Bunkyo Ku, Tokyo 113, Japan

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 26期

关键词：

D O I：

10.1039/b618251h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Normally disfavored 5-endo-trig cyclizations proceed in N- homoallylsulfonamides bearing a CF3, CCl3, CO2Et or CN group at the C-3 position, via an intramolecular S(N)2'-type or addition reaction to construct pyrrolidine rings, even though the system allows a more favorable 5-exo-trig pathway.

引用

页码：2698 / 2700

页数：3

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