Antisense and therapeutic oligonucleotides: toward a gene-targeting cancer clinic

被引：11

作者：

Cho-Chung, YS ^{[1
]}

机构：

[1] NCI, Cellular Biochem Sect, Tumor Immunol & Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2000年 / 10卷 / 11期

关键词：

antisense; cancer; chemotherapy; DNA methylase; oligonucleotides; oncogenes; protein kinase; transcription factor decoy;

D O I：

10.1517/13543776.10.11.1711

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dramatic progress is being made in the identification of genes that are involved in oncogenesis and cancer progression. Novel therapeutic oligonucleotides, such as those that can block the expression of specific target genes (antisense) and those that can interfere with a specific enhancer element-directed transcription in vivo (triple helix-forming or decoy), are potentially powerful tools for the therapeutic manipulation of genes associated with cancer. Such a gene-targeting approach is no longer a wishful dream, but a reality that will drive clinical medicine in the foreseeable future.

引用

页码：1711 / 1724

页数：14

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