Antisense and therapeutic oligonucleotides: toward a gene-targeting cancer clinic

被引：11
作者：
Cho-Chung, YS [1 ]
机构：
[1] NCI, Cellular Biochem Sect, Tumor Immunol & Biol Lab, NIH, Bethesda, MD 20892 USA
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2000年 / 10卷 / 11期
关键词：
antisense; cancer; chemotherapy; DNA methylase; oligonucleotides; oncogenes; protein kinase; transcription factor decoy;
D O I：
10.1517/13543776.10.11.1711
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Dramatic progress is being made in the identification of genes that are involved in oncogenesis and cancer progression. Novel therapeutic oligonucleotides, such as those that can block the expression of specific target genes (antisense) and those that can interfere with a specific enhancer element-directed transcription in vivo (triple helix-forming or decoy), are potentially powerful tools for the therapeutic manipulation of genes associated with cancer. Such a gene-targeting approach is no longer a wishful dream, but a reality that will drive clinical medicine in the foreseeable future.
引用
收藏
页码：1711 / 1724
页数：14
相关论文
共 165 条
[1]  
Agadir A, 1997, CANCER RES, V57, P3444
[2]   Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies [J].
Agrawal, S ;
Jiang, ZW ;
Zhao, QY ;
Shaw, D ;
Cai, QY ;
Roskey, A ;
Channavajjala, L ;
Saxinger, C ;
Zhang, RW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2620-2625
[3]   Antisense therapeutics [J].
Agrawal, S ;
Zhao, QY .
CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (04) :519-528
[4]  
Agrawal S., 1998, ANTISENSE RES APPL, P525
[5]   In vivo studies with antisense oligonucleotides [J].
Akhtar, S ;
Agrawal, S .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (01) :12-18
[6]   Protein kinase A-Iα subunit-directed antisense inhibition of ovarian cancer cell growth:: crosstalk with tyrosine kinase signaling pathway [J].
Alper, Ö ;
Hacker, NF ;
Cho-Chung, YS .
ONCOGENE, 1999, 18 (35) :4999-5004
[7]  
Anderson Carl W., 1992, Critical Reviews in Eukaryotic Gene Expression, V2, P283
[8]  
[Anonymous], 1997, BIOCH BIOPHYSICA ACT
[9]   Concurrent replication and methylation at mammalian origins of replication [J].
Araujo, FD ;
Knox, JD ;
Szyf, M ;
Price, GB ;
Zannis-Hadjopoulos, M .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (06) :3475-3482
[10]   ACTIVATION OF CAMP AND MITOGEN RESPONSIVE GENES RELIES ON A COMMON NUCLEAR FACTOR [J].
ARIAS, J ;
ALBERTS, AS ;
BRINDLE, P ;
CLARET, FX ;
SMEAL, T ;
KARIN, M ;
FERAMISCO, J ;
MONTMINY, M .
NATURE, 1994, 370 (6486) :226-229
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