The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

被引：32

作者：

Burman, Joachim ^{[1
,2
,3
]}

Svensson, Emma ^{[3
]}

Fransson, Moa ^{[3
]}

Loskog, Angelica S. I. ^{[3
]}

Zetterberg, Henrik ^{[4
,5
]}

Raininko, Raili ^{[6
]}

Svenningsson, Anders ^{[7
,8
]}

Fagius, Jan ^{[1
,2
]}

Mangsbo, Sara M. ^{[3
]}

机构：

[1] Uppsala Univ, Dept Neurosci, Uppsala, Sweden

[2] Univ Uppsala Hosp, Dept Neurol, SE-75185 Uppsala, Sweden

[3] Uppsala Univ, Sci Life Labs, Dept Immunol Genet & Pathol, Uppsala, Sweden

[4] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Molndal, Sweden

[5] UCL Inst Neurol, London WC1N 3BG, England

[6] Uppsala Univ, Dept Radiol, Uppsala, Sweden

[7] Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden

[8] Univ Hosp Northern Sweden, Umea, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 277卷 / 1-2期

关键词：

Cerebrospinal fluid; Cytokines; Magnetic resonance imaging; Multiple sclerosis; STEM-CELL TRANSPLANTATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; TH17; CELLS; DISEASE; EXPRESSION; CHEMOKINES; LESIONS; IL-27; DEMYELINATION;

D O I：

10.1016/j.jneuroim.2014.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this cross-sectional study, we wanted to identify key cytokines characteristic of different stages of multiple sclerosis (MS). To this end, cerebrospinal fluid from patients with MS was investigated with a multiplexed fluorescent bead-based immunoassay. In total 43 cytokines were assessed and related to clinical and imaging data. Increased levels of CCL22, CXCL10 and sCD40L characterized relapsing-remitting MS patients with the presence of gadolinium-enhancing lesions; decreased CCL2 and increased CXCL1 and CCL5 were typical of relapsing-remitting MS patients irrespectively of the presence of gadolinium-enhancing lesions. These homogenous patterns of cytokine activation do not conform to conventional Th1/Th2/Th17 responses. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：153 / 159

页数：7

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