Circadian gene expression patterns of melanopsin and pinopsin in the chick pineal gland

被引:26
作者
Holthues, H [1 ]
Engel, L [1 ]
Spessert, R [1 ]
Vollrath, L [1 ]
机构
[1] Johannes Gutenberg Univ Mainz, Dept Anat, D-55099 Mainz, Germany
关键词
melanopsin; pinopsin; gene expression; pineal gland; circadian rhythm; chick;
D O I
10.1016/j.bbrc.2004.11.022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The directly light-sensitive chick pineal gland contains at least two photopigments. Pinopsin seems to mediate the acute inhibitory effect of light on melatonin synthesis, whereas melanopsin may act by phase-shifting the intrapineal circadian clock. In the present study we have investigated, by means of quantitative RT-PCR, the daily rhythm of photopigment gene expression as monitored by mRNA levels. Under a 12-h light/12-h dark cycle, the mRNA levels of both pigments were 5-fold higher in the transitional phase from light to dark than at night, both in vivo and in vitro. Under constant darkness in vivo and in vitro, the peak of pinopsin mRNA levels was attenuated, whereas that of melanopsin was not. Thus, whereas the daily rhythm of pinopsin gene expression is dually regulated by light plus the intrapineal circadian oscillator, that of melanopsin appears to depend solely on the oscillator. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:160 / 165
页数:6
相关论文
共 50 条
  • [21] Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland
    Carstensen, Mikkel B.
    Hertz, Henrik
    Bering, Tenna
    Moller, Morten
    Rohde, Kristian
    Klein, David C.
    Coon, Steven L.
    Rath, Martin F.
    [J]. JOURNAL OF PINEAL RESEARCH, 2020, 68 (02)
  • [22] Embryonic development of the chick pineal gland throughout the incubation periods
    Colakoglu, Fatma
    Selcuk, Muhammet Lutfi
    [J]. ANATOMIA HISTOLOGIA EMBRYOLOGIA, 2024, 53 (01)
  • [23] The role of PACAP in the control of circadian expression of clock genes in the chicken pineal gland
    Nagy, Andras D.
    Csernus, Valer J.
    [J]. PEPTIDES, 2007, 28 (09) : 1767 - 1774
  • [24] The presence of histamine and tele-methylhistamine in the pineal gland of chick
    Zawilska, JB
    WoldanTambor, A
    Sek, B
    OrszulakMichalak, D
    Mackova, M
    Nowak, JZ
    [J]. ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 1996, 56 (03) : 691 - 695
  • [25] Circadian and photic regulation of cryptochrome mRNAs in the rat pineal gland
    Nakamura, TJ
    Shinohara, K
    Funabashi, T
    Mitsushima, D
    Kimura, F
    [J]. NEUROSCIENCE RESEARCH, 2001, 41 (01) : 25 - 32
  • [26] Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland
    Rath, Martin F.
    [J]. JOURNAL OF PINEAL RESEARCH, 2024, 76 (03)
  • [27] 5-Methoxytryptophol rhythms in the chick pineal gland: effect of environmental lighting conditions
    Zawilska, JB
    Skene, DJ
    Nowak, JZ
    [J]. NEUROSCIENCE LETTERS, 1998, 251 (01) : 33 - 36
  • [28] Role of circadian activation of mitogen-activated protein kinase in chick pineal clock oscillation
    Sanada, K
    Hayashi, Y
    Harada, Y
    Okano, T
    Fukada, Y
    [J]. JOURNAL OF NEUROSCIENCE, 2000, 20 (03) : 986 - 991
  • [29] Features of the circadian clock in the avian pineal gland
    Csernus, V
    Faluhelyi, N
    Nagy, AD
    [J]. TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, 2005, 1040 : 281 - 287
  • [30] Light-dependent changes in the chick pineal temperature and the expression of cHsp90α gene:: A potential contribution of in vivo temperature change to the photic-entrainment of the chick pineal circadian clock
    Doi, M
    Nakajima, Y
    Okano, T
    Fukada, Y
    [J]. ZOOLOGICAL SCIENCE, 2002, 19 (06) : 633 - 641