The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients

被引：18

作者：

Lopez-Martinez, Rocio ^{[1
]}

Albaiceta, Guillermo M. ^{[3
,5
,6
,7
,8
]}

Amado-Rodriguez, Laura ^{[3
,5
,7
,8
]}

Cuesta-Llavona, Elias ^{[2
,5
]}

Gomez, Juan ^{[2
,5
]}

Garcia-Clemente, Marta ^{[4
,5
]}

Vazquez-Coto, Daniel ^{[1
]}

Alvarez, Victoria ^{[1
,5
]}

Coto, Eliecer ^{[2
,5
,6
]}

机构：

[1] Hosp Univ Cent Asturias, Inmunol, Oviedo, Spain

[2] Hosp Univ Cent Asturias, Genet Mol, Oviedo, Spain

[3] Hosp Univ Cent Asturias, Unidad Cuidados Intens Cardiol, Oviedo, Spain

[4] Hosp Univ Cent Asturias, Neumol, Oviedo, Spain

[5] Inst Invest Sanitaria Principado Asturias, ISPA, Oviedo, Spain

[6] Univ Oviedo, Oviedo, Spain

[7] Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain

[8] Inst Univ Oncol Principado Asturias, Oviedo, Spain

来源：

CLINICAL IMMUNOLOGY | 2022年 / 236卷

关键词：

COVID-19; FCGR2A; Gene polymorphism; Genetic association; HEPARIN-INDUCED THROMBOCYTOPENIA; FC-GAMMA-RIIA; SUSCEPTIBILITY; RECEPTORS; HIT;

D O I：

10.1016/j.clim.2022.108954

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polymorphisms of Fc gamma receptors have been associated with variable responses to infections. We determined the association of functional polymorphisms rs1801274 in the FCGR2A and rs396991 in the FCGR3A with COVID-19 severity. This study involved 453 patients with severe COVID-19, in which the FCGR2A rs1801274 G-allele (131-Arg) was significantly associated with death (p = 0.02, OR = 1.47). This effect was independent of age and increased IL6 and D-Dimer levels. This study suggests that the FCGR2A gene might be associated with the risk of death among COVID-19 patients. Our study has several limitations, mainly the limited number of patients and the inclusion of a single population. It is thus necessary to confirm this result in larger cohorts from different populations.

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页数：4

相关论文

共 26 条

[1] Fc gamma RIIA H/R(131) polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis [J].

Arepally, G ;

McKenzie, SE ;

Jiang, XM ;

Poncz, M ;

Cines, DB .

BLOOD, 1997, 89 (02) :370-375

[2] Human platelet IgG Fc receptor FcRIIA in immunity and thrombosis [J].

Arman, M. ;

Krauel, K. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2015, 13 (06) :893-908

[3]

Bachelot-Loza C, 1998, THROMB HAEMOSTASIS, V79, P523

[4] Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis [J].

Beppler, Jaqueline ;

Koehler-Santos, Patricia ;

Pasqualim, Gabriela ;

Matte, Ursula ;

Alho, Clarice Sampaio ;

Dias, Fernando Suparregui ;

Kowalski, Thayne Woycinck ;

Velasco, Irineu Tadeu ;

Monteiro, Renato C. ;

da Silva, Fabiano Pinheiro .

INFLAMMATION, 2016, 39 (02) :518-525

[5] Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19 [J].

Berger, Jeffrey S. ;

Kunichoff, Dennis ;

Adhikari, Samrachana ;

Ahuja, Tania ;

Amoroso, Nancy ;

Aphinyanaphongs, Yindalon ;

Cao, Meng ;

Goldenberg, Ronald ;

Hindenburg, Alexander ;

Horowitz, James ;

Parnia, Sam ;

Petrilli, Christopher ;

Reynolds, Harmony ;

Simon, Emma ;

Slater, James ;

Yaghi, Shadi ;

Yuriditsky, Eugene ;

Hochman, Judith ;

Horwitz, Leora, I .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2020, 40 (10) :2539-2547

[6] Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcγRIIA and FcαRI [J].

Bohlaender, Fabian ;

Riehl, Dennis ;

Weissmueller, Sabrina ;

Gutscher, Marcus ;

Schuettrumpf, Jorg ;

Faust, Stefanie .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[7] Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses [J].

Bruhns, Pierre ;

Iannascoli, Bruno ;

England, Patrick ;

Mancardi, David A. ;

Fernandez, Nadine ;

Jorieux, Sylvie ;

Daeron, Marc .

BLOOD, 2009, 113 (16) :3716-3725

[8] Heparin-induced thrombocytopenia:: New insights into the impact of the FcγRIIa-R-H131 polymorphism [J].

Carlsson, LE ;

Santoso, S ;

Baurichter, G ;

Kroll, H ;

Papenberg, S ;

Eichler, P ;

Westerdaal, NAC ;

Kiefel, V ;

van de Winkel, JGJ ;

Greinacher, A .

BLOOD, 1998, 92 (05) :1526-1531

[9] Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 units [J].

Carubbi, Francesco ;

Salvati, Lia ;

Alunno, Alessia ;

Maggi, Fabio ;

Borghi, Erika ;

Mariani, Rinalda ;

Mai, Francesca ;

Paoloni, Maurizio ;

Ferri, Claudio ;

Desideri, Giovambattista ;

Cicogna, Sabrina ;

Grassi, Davide .

SCIENTIFIC REPORTS, 2021, 11 (01)

[10] Harnessing the immune system via FcγR function in immune therapy: a pathway to next-gen mAbs [J].

Chenoweth, Alicia M. ;

Wines, Bruce D. ;

Anania, Jessica C. ;

Hogarth, P. .

IMMUNOLOGY AND CELL BIOLOGY, 2020, 98 (04) :287-304