Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis

被引：108

作者：

Inao, M ^{[1
]}

Mochida, S ^{[1
]}

Matsui, A ^{[1
]}

Eguchi, Y ^{[1
]}

Yulutuz, Y ^{[1
]}

Wang, YH ^{[1
]}

Naiki, K ^{[1
]}

Kakinuma, T ^{[1
]}

Fujimori, K ^{[1
]}

Nagoshi, S ^{[1
]}

Fujiwara, K ^{[1
]}

机构：

[1] Saitama Med Sch, Dept Internal Med 3, Iruma, Saitama 3500495, Japan

来源：

JOURNAL OF HEPATOLOGY | 2004年 / 41卷 / 04期

关键词：

TJ-135; Inchin-ko-to; liver fibrosis; hepatic stellate cells;

D O I：

10.1016/j.jhep.2004.06.033

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Inchin-ko-to (TJ-135) is an herbal medicine used in Japan for treatment of icteric patients with cirrhosis. Its efficacy as an anti-fibrogenic drug was evaluated in relation to stellate cell activation. Methods/Results: Liver fibrosis was induced in rats by repeated injections of carbon tetrachloride (CCl4) Or Pigserum. Oral administration of TJ-135 improved the mortality of rats given CCl4 with reduced extents of liver necrosis and fibrosis. Similar improvement of liver fibrosis was found in rats given pig-serum showing no liver necrosis. DNA synthesis of stellate cells activated in vitro after isolation from normal rat liver was decreased by culture with TJ-135 in a dose-related manner, accompanied by decreased smooth muscle alpha actin expression and contractility. Such attenuation was not found in the cells cultured with geniposide, an iridoid compound of TJ-135, but genipin, an aglycone of geniposide formed in the gut by action of bacterial flora, markedly decreased stellate cell activation without affecting synthesis of proteins other than collagen. Conclusions: TJ-135 may be useful for treatment of liver fibrosis and portal hypertension through suppression of activated hepatic stellate cell function by genipin, an absorbed form of its component. (C) 2004 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：584 / 591

页数：8

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