Solute carrier family 12 member 8 (SLC12A8) is a potential biomarker and related to tumor immune cell infiltration in bladder cancer

被引：16

作者：

Zhang, Qian ^{[1
]}

Liu, Yunen ^{[2
]}

Chen, Peng ^{[4
]}

Shi, Xiuyun ^{[2
]}

Liu, Ying ^{[2
]}

Shi, Lin ^{[2
]}

Cong, Peifang ^{[2
]}

Mao, Shun ^{[2
]}

Tong, Cangci ^{[2
]}

Du, Cheng ^{[3
]}

Hou, Mingxiao ^{[1
,2
]}

机构：

[1] Northeastern Univ, Coll Med & Biol Informat Engn, Shenyang, Liaoning, Peoples R China

[2] Gen Hosp Northern Theater Command, Lab Rescue Ctr Severe Wound & Trauma PLA, Emergency Med Dept, Shenyang, Liaoning, Peoples R China

[3] Gen Hosp Northern Theater Command, Dept Oncol, Shenyang, Liaoning, Peoples R China

[4] Gen Hosp Northern Theater Command, Dept Urol, Shenyang, Liaoning, Peoples R China

来源：

BIOENGINEERED | 2021年 / 12卷 / 01期

关键词：

bladder cancer; tcga; cibersort; timer2; 0; immune infiltration; immune checkpoint inhibitor; SIGNATURE; IDENTIFICATION; EXPRESSION; TARGETS;

D O I：

10.1080/21655979.2021.1962485

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The solute carrier family has been reported to play critical roles in the progression of several cancers; however, the relationship between solute carrier family 12 member 8 (SLC12A8) and bladder cancer (BC) has not been clearly confirmed. This study explores the prognostic value of SLC12A8 for BC and its correlation with immune cell infiltration. We found that the expression of SLC12A8 mRNA was significantly overexpressed in BC tissues compared with noncancerous tissues in multiple public databases, and the result was validated using real-time PCR and immunohistochemistry (IHC). The Kaplan-Meier method and Cox proportional hazards models were used to evaluate the prognostic value of SLC12A8 for BC. The high expression of SLC12A8 led to a shorter overall survival time and was an unfavorable prognostic biomarker for BC. The mechanisms of SLC12A8 promoting tumorigenesis were investigated by Gene Set Enrichment Analysis (GSEA). Moreover, the correlations of SLC12A8 expression with the tumor-infiltrating immune cells (TICs) in BC were explored using TIMER 2.0 and CIBERSORT. SLC12A8 was associated with CD4+ T cells, dendritic cells, neutrophils, and macrophages infiltration. The expression of SLC12A8 was positively correlated with crucial immune checkpoint molecules. In conclusion, SLC12A8 might be an unfavorable prognostic biomarker in BC related to tumor immune cell infiltration.

引用

页码：4946 / 4961

页数：16

共 56 条

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