Characterization of magnetic nanoparticles from Magnetospirillum Gryphiswaldense as potential theranostics tools

被引：34

作者：

Orlando, T. ^{[1
,2
,3
]}

Mannucci, S. ^{[4
,5
]}

Fantechi, E. ^{[6
,7
]}

Conti, G. ^{[4
,5
]}

Tambalo, S. ^{[4
,5
]}

Busato, A. ^{[4
,5
]}

Innocenti, C. ^{[6
,7
]}

Ghin, L. ^{[5
,8
]}

Bassi, R. ^{[5
,8
]}

Arosio, P. ^{[9
,10
]}

Orsini, F. ^{[9
,10
]}

Sangregorio, C. ^{[7
,11
]}

Corti, M. ^{[1
,2
]}

Casula, M. F. ^{[12
,13
]}

Marzola, P. ^{[5
,14
]}

Lascialfari, A. ^{[9
,10
]}

Sbarbati, A. ^{[4
,5
]}

机构：

[1] Univ Pavia, Dept Phys, Via Palestro 3, I-27100 Pavia, Italy

[2] Univ Pavia, INSTM, Via Palestro 3, I-27100 Pavia, Italy

[3] Max Planck Inst Biophys Chem, Res Grp EPR Spect, D-37077 Gottingen, Germany

[4] Univ Verona, Dept Neurol & Movement Sci, I-37134 Verona, Italy

[5] Univ Verona, INSTM, I-37134 Verona, Italy

[6] Ugo Schiff Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, FI, Italy

[7] INSTM, I-50019 Sesto Fiorentino, FI, Italy

[8] Univ Verona, Dept Biotechnol, I-37134 Verona, Italy

[9] Univ Milan, Dept Phys, I-20133 Milan, Italy

[10] Univ Milan, INSTM, I-20133 Milan, Italy

[11] CNR ICCOM, I-50019 Sesto Fiorentino, FI, Italy

[12] Univ Cagliari, Dept Chem & Geol Sci, I-09042 Monserrato, CA, Italy

[13] Univ Cagliari, INSTM, I-09042 Monserrato, CA, Italy

[14] Univ Verona, Dept Comp Sci, I-37134 Verona, Italy

来源：

CONTRAST MEDIA & MOLECULAR IMAGING | 2016年 / 11卷 / 02期

关键词：

magnetosomes; relaxometry; contrast agent; MRI; hyperthermia; theranostics; IRON-OXIDE NANOPARTICLES; MAGNETOTACTIC BACTERIA; VERWEY TRANSITION; MAGNETOSOMES; CANCER; RESONANCE; THERAPY; CHAINS; TUMORS; FIELD;

D O I：

10.1002/cmmi.1673

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We investigated the theranostic properties of magnetosomes (MNs) extracted from magnetotactic bacteria, promising for nanomedicine applications. Besides a physico-chemical characterization, their potentiality as mediators for magnetic fluid hyperthermia and contrast agents for magnetic resonance imaging, both in vitro and in vivo, are here singled out. The MNs, constituted by magnetite nanocrystals arranged in chains, show a superparamagnetic behaviour and a clear evidence of Verwey transition, as signature of magnetite presence. The phospholipid membrane provides a good protection against oxidation and the MNs oxidation state is stable over months. Using an alternate magnetic field, the specific absorption rate was measured, resulting among the highest reported in literature. The MRI contrast efficiency was evaluated by means of the acquisition of complete NMRD profiles. The transverse relaxivity resulted as high as the one of a former commercial contrast agent. The MNs were inoculated into an animal model of tumour and their presence was detected by magnetic resonance images two weeks after the injection in the tumour mass. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：139 / 145

页数：7

共 34 条

[1] Difference between the magnetic properties of the magnetotactic bacteria and those of the extracted magnetosomes:: Influence of the distance between the chains of magnetosomes [J].