The biology and treatment of EML4-ALK non-small cell lung cancer

被引：486

作者：

Sasaki, Takaaki ^{[1
,2
]}

Rodig, Scott J. ^{[3
]}

Chirieac, Lucian R. ^{[3
]}

Janne, Pasi A. ^{[1
,2
,4
,5
]}

机构：

[1] Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

来源：

EUROPEAN JOURNAL OF CANCER | 2010年 / 46卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Non-small cell lung carcinoma; Translocation; Kinase inhibitor; Clinical trial; GROWTH-FACTOR-RECEPTOR; CLINICOPATHOLOGICAL FEATURES; FUSION GENE; ANAPLASTIC LYMPHOMA; TUMOR-SUPPRESSOR; MUTATIONS; ALK; KINASE; KRAS; ADENOCARCINOMA;

D O I：

10.1016/j.ejca.2010.04.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK),has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often detected in never smokers with lung cancer and has unique pathologic features. EML4-ALK is oncogenic both in vitro and in vivo and ALK kinase inhibitors are quite effective in pre-clinical model systems. More recently ALK inhibitors have entered clinical development and remarkably clinical efficacy has been observed in NSCLC patients harbouring EML4-ALK translocations. This review will focus on the biology, clinical characteristics, diagnosis and treatment of EML4-ALK NSCLC. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1773 / 1780

页数：8

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