Identification of genetic biomarkers in urine for early detection of prostate cancer

Prostate cancer screening is a challenging and vital issue in the aspects of the current tests and risk assess-ments. Prostate cancer risk assessments are currently carried out by using blood, urine and tissue biomark-ers with radiological imaging methods. Here, we introduce a novel noninvasive screening tool for a further in-depth selection of eligible cases for prostate biopsies which is based on sequencing somatic and hered-itary HOXB13 mutations in urine samples. This approach provides diagnostic information to the physician about the presence of prostate cancer while aiming to screen for specific prostate biopsies and save biop-sies potentially when there are no mutations related to prostate cancer. Findings suggest that this method is reliable, cost-effective, and has a promising potential in prostate cancer screening. (c) 2020 Elsevier Inc. All rights reserved.